Recommended positive controls: HeLa, HeLa membrane.
Predicted reactivity: Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes omega-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4 as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). CYP4F2 participates in the omega-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.
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Protein Aliases: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; Arachidonic acid omega-hydroxylase; CPF2; CYPIVF2; cytochrome P450; Cytochrome P450 4F2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; Cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase; leukotriene B4 omega-hydroxylase; Leukotriene-B(4) 20-monooxygenase 1; Leukotriene-B(4) omega-hydroxylase 1; leukotriene-B4 20-monooxygenase; Phylloquinone omega-hydroxylase CYP4F2; polypeptide 2; subfamily IVF
Gene Aliases: CPF2; CYP4F2
UniProt ID: (Human) P78329
Entrez Gene ID: (Human) 8529