CYP7A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body.
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Protein Aliases: 24-hydroxycholesterol 7-alpha-hydroxylase; cholesterol 7 alpha hydroxylase; cholesterol 7-alpha hydroxylase; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; CYPVII; cytochrome P450 (cholesterol hydroxylase 7 alpha); Cytochrome P450 7A1; cytochrome P450, 7a1; cytochrome P450, family 7, subfamily A, polypeptide 1; cytochrome P450, subfamily VIIA polypeptide 1
Gene Aliases: CHAP; CP7A; CYP7; CYP7A1; CYP7S1; CYPVII
Molecular Function: oxygenase