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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
CYP7B1 Fusion Protein Ag19374 (96-403 aa encoded by BC136574) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.4 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: PFQYQLVIK NHKQLSFRVF SNKLLEKAFS ISQLQKNHDM NDELHLCYQF LQGKSLDILL ESMMQNLKQV FEPQLLKTTS WDTAELYPFC SSIIFEITFT TIYGKVIVCD NNKFISELRD DFLKFDDKFA YLVSNIPIEL LGNVKSIREK IIKCFSSEKL AKMQGWSEVF QSRQDVLEKY YVHEDLEIGA HHLGFLWASV ANTIPTMFWA MYYLLRHPEA MAAVRDEIDR LLQSTGQKKG SGFPIHLTRE QLDSLICLES SIFEALRLSS YSTTIRFVEE DLTLSSETGD YCVRKGDLVA IFPPVLHGD (96-403 aa encoded by BC136574)
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; Cytochrome P450 7B1; cytochrome P450, 7b1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1; HCT-1; Hippocampal transcript 1 protein; Oxysterol 7-alpha-hydroxylase
Gene Aliases: AW261589; CBAS3; CP7B; CYP7B1; D3Ertd552e; hct-1; SPG5A
UniProt ID: (Human) O75881, (Mouse) Q60991
Entrez Gene ID: (Human) 9420, (Mouse) 13123
Molecular Function:
oxygenase
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