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Proteintech
CYP7B1 Polyclonal Antibody
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Product Details
24889-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CYP7B1 Fusion Protein Ag19374 (96-403 aa encoded by BC136574)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PFQYQLVIK NHKQLSFRVF SNKLLEKAFS ISQLQKNHDM NDELHLCYQF LQGKSLDILL ESMMQNLKQV FEPQLLKTTS WDTAELYPFC SSIIFEITFT TIYGKVIVCD NNKFISELRD DFLKFDDKFA YLVSNIPIEL LGNVKSIREK IIKCFSSEKL AKMQGWSEVF QSRQDVLEKY YVHEDLEIGA HHLGFLWASV ANTIPTMFWA MYYLLRHPEA MAAVRDEIDR LLQSTGQKKG SGFPIHLTRE QLDSLICLES SIFEALRLSS YSTTIRFVEE DLTLSSETGD YCVRKGDLVA IFPPVLHGD (96-403 aa encoded by BC136574)
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; cytochrome p450; Cytochrome P450 7B1; cytochrome P450, 7b1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1; HCT-1; Hippocampal transcript 1 protein; Oxysterol 7-alpha-hydroxylase
Gene Aliases: AW261589; CBAS3; CP7B; CYP7B1; D3Ertd552e; hct-1; SPG5A
UniProt ID: (Human) O75881, (Mouse) Q60991
Entrez Gene ID: (Human) 9420, (Mouse) 13123
monooxygenase activity
iron ion binding
protein binding
steroid hydroxylase activity
oxysterol 7-alpha-hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
heme binding
24-hydroxycholesterol 7alpha-hydroxylase activity
25-hydroxycholesterol 7alpha-hydroxylase activity
metal ion binding
oxygenase
lipid metabolic process
steroid biosynthetic process
bile acid biosynthetic process
steroid metabolic process
cholesterol metabolic process
sterol metabolic process
intracellular estrogen receptor signaling pathway
negative regulation of intracellular estrogen receptor signaling pathway
B cell chemotaxis
cholesterol homeostasis
epithelial cell proliferation
positive regulation of epithelial cell proliferation
prostate gland epithelium morphogenesis
digestion
memory
circadian rhythm
oxidation-reduction process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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