Positive Control: HeLa (1X Brefeldin A for 24hr)
Predicted Reactivity: Chicken (81%), Chimpanzee (99%), Bovine (92%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.
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Protein Aliases: 61 ; angiogenic inducer; anigogenic inducer; CCN family member 1; CCN1; CYR61; cysteine rich protein 61; cysteine-rich; Cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; GIG1; IBP-10; IGF-binding protein 10; IGFBP-10; IGFBP10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1
Gene Aliases: CCN1; CYR61; GIG1; IGFBP10