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Invitrogen
CYR61 Polyclonal Antibody
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FIGURE: 1 / 7
CYR61 Antibody (PA5150197) in IHC (P)
Immunohistochemistry analysis of CYR61 in paraffin-embedded Human Bile duct cancer tissue. Samples were incubated with CYR61 Polyclonal (Product # PA5150197) antibody using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5150197
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) (Leu178-Asp381)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCN family member 1; Cellular communication network factor 1; Cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; IBP-10; IGF-binding protein 10; IGFBP-10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1
Gene Aliases: CCN1; CYR61; GIG1; IGFBP10
UniProt ID: (Human) O00622
Entrez Gene ID: (Human) 3491
regulation of cell growth
osteoblast differentiation
positive regulation of protein phosphorylation
intussusceptive angiogenesis
atrioventricular valve morphogenesis
apoptotic process involved in heart morphogenesis
ventricular septum development
chemotaxis
cell adhesion
cell-cell signaling
cell proliferation
anatomical structure morphogenesis
positive regulation of phospholipase activity
positive regulation of cell-substrate adhesion
extracellular matrix organization
positive regulation of cell migration
positive regulation of BMP signaling pathway
positive regulation of osteoblast proliferation
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
wound healing, spreading of cells
positive regulation of osteoblast differentiation
positive regulation of protein kinase activity
positive regulation of transcription from RNA polymerase II promoter
atrial septum morphogenesis
negative regulation of cell death
chondroblast differentiation
chorio-allantoic fusion
labyrinthine layer blood vessel development
positive regulation of cartilage development
regulation of ERK1 and ERK2 cascade
reactive oxygen species metabolic process
positive regulation of ceramide biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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