Proteintech

CYR61/CCN1 Polyclonal Antibody

CYR61/CCN1 Antibody in Immunocytochemistry (ICC/IF)

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CYR61/CCN1 Antibody (26689-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed MCF-7 cells using 26689-1-AP (CYR61/CCN1 antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CYR61/CCN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CYR61/CCN1 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

26689-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 23 publications 23 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 5 publications 5 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CYR61/CCN1 Fusion Protein Ag25129 (165-239 aa encoded by BC001271)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQC (165-239 aa encoded by BC001271)

Target Information

CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CCN1 secreted by human adipose-derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway.

International wound journal

Yang Y,Li S,Sun X,Zhang L,Chen M,Fu H

Mon May 01 00:00:00 UTC 2023

CCN1 secreted by human adipose-derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway.

International wound journal

Yang Y,Li S,Sun X,Zhang L,Chen M,Fu H

Mon May 01 00:00:00 UTC 2023

Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.

Scientific reports

Pusec CM,Ilievski V,De Jesus A,Farooq Z,Zapater JL,Sweis N,Ismail H,Khan MW,Ardehali H,Cordoba-Chacon J,Layden BT

Wed May 17 00:00:00 UTC 2023

miR-183-5p overexpression orchestrates collective invasion in salivary adenoid cystic carcinoma through the FAT1/YAP1 signaling pathway.

Biochemical and biophysical research communications

Chen BJ,Jiang J,Li T,Jiang HJ,Liang XH,Tang YL

Sun May 07 00:00:00 UTC 2023

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

Cancer communications (London, England)

Guo Y,Cui Y,Li Y,Jin X,Wang D,Lei M,Chen F,Liu Y,Xu J,Yao G,Zeng G,Chen X

Mon May 01 00:00:00 UTC 2023

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

Cancer communications (London, England)

Guo Y,Cui Y,Li Y,Jin X,Wang D,Lei M,Chen F,Liu Y,Xu J,Yao G,Zeng G,Chen X

Mon May 01 00:00:00 UTC 2023

Restraint of chaperonin containing T-complex protein-1 subunit 3 has antitumor roles in non-small cell lung cancer via affection of YAP1.

Toxicology and applied pharmacology

Shi H,Zhang Y,Wang Y,Fang P,Liu Y,Li W

Tue Mar 15 00:00:00 UTC 2022

Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex.

Human molecular genetics

Terry BK,Park R,Cho SH,Crino PB,Kim S

Wed Jun 22 00:00:00 UTC 2022

USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ.

International journal of biological sciences

Yuan P,Feng Z,Huang H,Wang G,Chen Z,Xu G,Xie Z,Jie Z,Zhao X,Ma Q,Wang S,Shen Y,Huang Y,Han Y,Ye H,Wang J,Shi P,Sun X

Thu Jun 02 00:00:00 UTC 2022

USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ.

International journal of biological sciences

Yuan P,Feng Z,Huang H,Wang G,Chen Z,Xu G,Xie Z,Jie Z,Zhao X,Ma Q,Wang S,Shen Y,Huang Y,Han Y,Ye H,Wang J,Shi P,Sun X

Thu Jun 02 00:00:00 UTC 2022

Patient-driven discovery of CCN1 to rescue cutaneous wound healing in diabetes via the intracellular EIF3A/CCN1/ATG7 signaling by nanoparticle-enabled delivery.

Biomaterials

Jiang JS,Zang J,Ru Y,Luo Y,Song JK,Luo Y,Fei XY,Zhang Z,Zhang Y,Yang D,Zhou M,Chen QL,Bai Y,Li YY,Kuai L,Li B

Thu Sep 01 00:00:00 UTC 2022

Patient-driven discovery of CCN1 to rescue cutaneous wound healing in diabetes via the intracellular EIF3A/CCN1/ATG7 signaling by nanoparticle-enabled delivery.

Biomaterials

Jiang JS,Zang J,Ru Y,Luo Y,Song JK,Luo Y,Fei XY,Zhang Z,Zhang Y,Yang D,Zhou M,Chen QL,Bai Y,Li YY,Kuai L,Li B

Thu Sep 01 00:00:00 UTC 2022

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Cancers

Ferrand N,Fert A,Morichon R,Radosevic-Robin N,Zaoui M,Sabbah M

Mon Mar 14 00:00:00 UTC 2022

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Cancers

Ferrand N,Fert A,Morichon R,Radosevic-Robin N,Zaoui M,Sabbah M

Mon Mar 14 00:00:00 UTC 2022

RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1.

Experimental and therapeutic medicine

Huang Y,Zou Y,Jie Z

Tue Feb 01 00:00:00 UTC 2022

AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.

Environmental toxicology

Fang P,Deng WJ,Fan N,Shi J,Shi HY,Ou L,Pan JL,Yang SY

Mon Nov 01 00:00:00 UTC 2021

Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling.

Environmental toxicology

Xu G,Seng Z,Zhang M,Qu J

Wed Dec 01 00:00:00 UTC 2021

Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.

Frontiers in cardiovascular medicine

Li H,Li T,Wang H,He X,Li Y,Wen S,Peng R,Nie Y,Lu Y,Yang H,Ye Y,Shi G,Chen Y

Tue Aug 31 00:00:00 UTC 2021

Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.

Frontiers in cardiovascular medicine

Li H,Li T,Wang H,He X,Li Y,Wen S,Peng R,Nie Y,Lu Y,Yang H,Ye Y,Shi G,Chen Y

Tue Aug 31 00:00:00 UTC 2021

Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.

Frontiers in cardiovascular medicine

Li H,Li T,Wang H,He X,Li Y,Wen S,Peng R,Nie Y,Lu Y,Yang H,Ye Y,Shi G,Chen Y

Tue Aug 31 00:00:00 UTC 2021

Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.

Frontiers in cardiovascular medicine

Li H,Li T,Wang H,He X,Li Y,Wen S,Peng R,Nie Y,Lu Y,Yang H,Ye Y,Shi G,Chen Y

Tue Aug 31 00:00:00 UTC 2021

MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.

Cancer biology & medicine

Yan F,Wang Q,Xia M,Ru Y,Hu W,Yan G,Xiong X,Zhang M,Wang J,Li Q,Zhang B,Wang H,Lin W,Wu G,Li X

Wed Dec 22 00:00:00 UTC 2021

MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.

Cancer biology & medicine

Yan F,Wang Q,Xia M,Ru Y,Hu W,Yan G,Xiong X,Zhang M,Wang J,Li Q,Zhang B,Wang H,Lin W,Wu G,Li X

Wed Dec 22 00:00:00 UTC 2021

The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.

Molecular therapy. Nucleic acids

Liu T,Yang Y,Xie Z,Luo Q,Yang D,Liu X,Zhao H,Wei Q,Liu Y,Li L,Wang Y,Wang F,Yu J,Xu J,Yu J,Yi P

Fri Dec 03 00:00:00 UTC 2021

Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes.

Virulence

Sun J,Zhang W,Tan Z,Zheng C,Tang Y,Ke X,Zhang Y,Liu Y,Li P,Hu Q,Wang H,Mao P,Zheng Z

Tue Dec 01 00:00:00 UTC 2020

Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes.

Virulence

Sun J,Zhang W,Tan Z,Zheng C,Tang Y,Ke X,Zhang Y,Liu Y,Li P,Hu Q,Wang H,Mao P,Zheng Z

Tue Dec 01 00:00:00 UTC 2020

Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes.

Virulence

Sun J,Zhang W,Tan Z,Zheng C,Tang Y,Ke X,Zhang Y,Liu Y,Li P,Hu Q,Wang H,Mao P,Zheng Z

Tue Dec 01 00:00:00 UTC 2020

Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes.

Virulence

Sun J,Zhang W,Tan Z,Zheng C,Tang Y,Ke X,Zhang Y,Liu Y,Li P,Hu Q,Wang H,Mao P,Zheng Z

Tue Dec 01 00:00:00 UTC 2020

Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.

Experimental and molecular pathology

Miao X,Zhang N

Tue Dec 01 00:00:00 UTC 2020

Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.

Experimental and molecular pathology

Miao X,Zhang N

Tue Dec 01 00:00:00 UTC 2020

A translational program that suppresses metabolism to shield the genome.

Nature communications

Balukoff NC,Ho JJD,Theodoridis PR,Wang M,Bokros M,Llanio LM,Krieger JR,Schatz JH,Lee S

Fri Nov 13 00:00:00 UTC 2020

A translational program that suppresses metabolism to shield the genome.

Nature communications

Balukoff NC,Ho JJD,Theodoridis PR,Wang M,Bokros M,Llanio LM,Krieger JR,Schatz JH,Lee S

Fri Nov 13 00:00:00 UTC 2020

A translational program that suppresses metabolism to shield the genome.

Nature communications

Balukoff NC,Ho JJD,Theodoridis PR,Wang M,Bokros M,Llanio LM,Krieger JR,Schatz JH,Lee S

Fri Nov 13 00:00:00 UTC 2020

A translational program that suppresses metabolism to shield the genome.

Nature communications

Balukoff NC,Ho JJD,Theodoridis PR,Wang M,Bokros M,Llanio LM,Krieger JR,Schatz JH,Lee S

Fri Nov 13 00:00:00 UTC 2020

A Novel Electrochemiluminescent Immunoassay Based on Target Transformation Assisted with Catalyzed Hairpin Assembly Amplification for the Ultrasensitive Bioassay.

ACS applied materials & interfaces

Lei HX,Niu CC,Li T,Wan YF,Liang WB,Yuan R,Liao P

Wed Aug 28 00:00:00 UTC 2019

Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.

Cells

Li M,Chen J,Yu X,Xu S,Li D,Zheng Q,Yin Y

Wed Apr 17 00:00:00 UTC 2019

Downregulation of CENPK suppresses hepatocellular carcinoma malignant progression through regulating YAP1.

OncoTargets and therapy

Wang J,Li H,Xia C,Yang X,Dai B,Tao K,Dou K

Fri Oct 14 00:00:00 UTC 2022

Quantitative Proteomics Implicates Rictor/mTORC2 in Cell Adhesion.

Journal of proteome research

Wang H,Shao X,He Q,Wang C,Xia L,Yue D,Qin G,Jia C,Chen R

Fri Oct 05 00:00:00 UTC 2018

Quantitative Proteomics Implicates Rictor/mTORC2 in Cell Adhesion.

Journal of proteome research

Wang H,Shao X,He Q,Wang C,Xia L,Yue D,Qin G,Jia C,Chen R

Fri Oct 05 00:00:00 UTC 2018

EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy.

Cell death & disease

Xia H,Dai X,Yu H,Zhou S,Fan Z,Wei G,Tang Q,Gong Q,Bi F

Thu Feb 15 00:00:00 UTC 2018

EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy.

Cell death & disease

Xia H,Dai X,Yu H,Zhou S,Fan Z,Wei G,Tang Q,Gong Q,Bi F

Thu Feb 15 00:00:00 UTC 2018

Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.

Cell discovery

Gao M,Chen M,Li C,Xu M,Liu Y,Cong M,Sang N,Liu S

Thu Oct 01 00:00:00 UTC 2020

Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.

Cell discovery

Gao M,Chen M,Li C,Xu M,Liu Y,Cong M,Sang N,Liu S

Thu Oct 01 00:00:00 UTC 2020

Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior.

BioMed research international

Man QW,Ma YQ,Liu JY,Zhao Y,Liu B,Zhao YF

Tue Feb 27 00:00:00 UTC 2018

Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior.

BioMed research international

Man QW,Ma YQ,Liu JY,Zhao Y,Liu B,Zhao YF

Tue Feb 27 00:00:00 UTC 2018

Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior.

BioMed research international

Man QW,Ma YQ,Liu JY,Zhao Y,Liu B,Zhao YF

Tue Feb 27 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: CCN family member 1; Cellular communication network factor 1; Cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; IBP-10; IGF-binding protein 10; IGFBP-10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1

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Gene Aliases: CCN1; CYR61; GIG1; IGFBP10

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UniProt ID: (Human) O00622

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Entrez Gene ID: (Human) 3491

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Function(s)

integrin binding insulin-like growth factor binding heparin binding extracellular matrix binding growth factor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CYR61/CCN1 Polyclonal Antibody

CYR61/CCN1 Antibody (26689-1-AP) in ICC/IF

Product Details

26689-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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