Recommended positive controls: 293T, HeLaS3, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
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Protein Aliases: Cys-LT1 receptor; CysLT 1; CysLT(1); CysLT1 receptor; CysLTR1; Cysteinyl leukotriene D4 receptor; Cysteinyl leukotriene receptor 1; G-protein coupled receptor HG55; HG55; HMTMF81; LTD4 receptor; LTD4R; MGC46139
Gene Aliases: CYSLT1; CYSLT1R; CYSLTR; CYSLTR1; HMTMF81
UniProt ID: (Human) Q9Y271
Entrez Gene ID: (Human) 10800