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Invitrogen
CYSLTR1 Polyclonal Antibody
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FIGURE: 1 / 1
CYSLTR1 Antibody (PA5-95939) in WB
Western blot analysis of CYSLTR1 in extracts of various cell lines. Samples were incubated with CYSLTR1 Polyclonal antibody (Product # PA5-95939) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.
Product Details
PA5-95939
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CYSLTR1 (NP_0066301)
Conjugate
Form
Liquid
Concentration
1.04 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MDETGNLTVS SATCHDTIDD FRNQVYSTLY SMISVVGFFG NGFVLYVLIK TYHKKSAFQV YMINLAVADL LCVCTLPLRV VYYVHKGIWL FGDFLCRLST; Positive Samples: U-937, A-549, BxPC-3, HeLa, Mouse kidney; Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cys-LT1 receptor; CysLT 1; CysLT(1); CysLT1 receptor; CysLTR1; cysteinyl leukotriene 1 receptor short isoform; Cysteinyl leukotriene D4 receptor; Cysteinyl leukotriene receptor 1; G-protein coupled receptor HG55; HG55; HMTMF81; LTD4 receptor; LTD4R; MGC46139
Gene Aliases: BB147369; CYSLT1; CYSLT1R; CYSLTR; CYSLTR1; HMTMF81
UniProt ID: (Human) Q9Y271, (Mouse) Q99JA4
Entrez Gene ID: (Human) 10800, (Mouse) 58861
circulatory system process
calcium ion transport
chemotaxis
defense response
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
respiratory gaseous exchange
leukotriene signaling pathway
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of angiogenesis
positive regulation of vasoconstriction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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