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AbboMax
CaM Kinase IV Polyclonal Antibody
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FIGURE: 1 / 1
CaM Kinase IV Antibody (500-10604) in IHC (PFA)
Immunohistochemistry: Human Breast carcinoma stained with Rabbit anti-CaM Kinase IV (Cat# 500-10604) at 1:100 for 30 min, RT. (Staining of formalin-fixed tissues requires boiling tissue section in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Product Details
500-10604
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide derived from aa 457-474 of rat CaM Kinase IV
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Jurkat cells. Brain.
Cellular location: Cytoplasmic and Nuclear.
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; Calcium/calmoduli; calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; Calmodulin-dependent protein kinase IV; Calspermin; CAM kinase IV; CAM kinase- GR; CAM kinase-GR; CaMK IV; EC 2.7.11.17; KCC4; kinase CaMK4; OTTHUMP00000222818
Gene Aliases: CAMK; CaMK IV; CAMK-GR; CAMK4; CAMKIV; Ccdpk; RATCCDPK
UniProt ID: (Human) Q16566, (Rat) P13234
Entrez Gene ID: (Human) 814, (Rat) 25050
adaptive immune response
myeloid dendritic cell cytokine production
protein phosphorylation
inflammatory response
signal transduction
long-term memory
peptidyl-serine phosphorylation
regulation of T cell differentiation in thymus
intracellular signal transduction
myeloid dendritic cell differentiation
regulation of osteoclast differentiation
positive regulation of transcription, DNA-templated
protein autophosphorylation
nucleocytoplasmic transport
neuron-neuron synaptic transmission
positive regulation of protein export from nucleus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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