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CaMK2 Antibody (BS-0541R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded mouse brain tissue; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with CaMK2 Polyclonal Antibody, Unconjugated (bs-0541R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody and D... View More
Product Details
BS-0541R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CaMK2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha CaM kinase II; alpha-CaMKII; Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase II gamma; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II alpha subunit; CaM kinase II beta subunit; CaM kinase II delta subunit; CaM kinase II subunit alpha; CaM kinase II subunit beta; CaM kinase II subunit delta; CaM kinase II subunit gamma; CaM-kinase II alpha chain; CaM-kinase II beta chain; CaM-kinase II delta chain; caM-kinase II gamma chain; CaMK II; CaMK-II alpha subunit; CaMK-II delta subunit; caMK-II subunit alpha; caMK-II subunit beta; caMK-II subunit delta; caMK-II subunit gamma; CaMKIINalpha; proline rich calmodulin-dependent protein kinase
Gene Aliases: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CAMK; CaMK II; CAMK-II; CAMK1; CAMK2; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMKA; CAMKB; CAMKD; CAMKG; Camki; CaMKII; Ck2b; KIAA0968; Kiaa4163; mKIAA0968; PK2CDD; PKCCD; R74975; RATCAMKI
UniProt ID: (Human) Q9UQM7, (Human) Q13554, (Human) Q13557, (Human) Q8N4I3, (Mouse) P11798, (Rat) P11275, (Rat) P08413, (Mouse) P28652, (Rat) P15791, (Mouse) Q6PHZ2, (Mouse) Q923T9, (Rat) P11730
Entrez Gene ID: (Human) 815, (Human) 816, (Human) 817, (Human) 818, (Mouse) 12322, (Rat) 25400, (Rat) 24245, (Mouse) 12323, (Rat) 24246, (Mouse) 108058, (Mouse) 12325, (Rat) 171140
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
calmodulin binding
ATP binding
kinase activity
glutamate receptor binding
protein homodimerization activity
actin binding
protein kinase binding
phospholipase binding
sodium channel inhibitor activity
titin binding
ion channel binding
nitric-oxide synthase binding
calcium-dependent protein serine/threonine phosphatase activity
nucleotide binding
protein kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
GTPase activating protein binding
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
MAPK cascade
response to ischemia
protein phosphorylation
calcium ion transport
Wnt signaling pathway, calcium modulating pathway
positive regulation of cardiac muscle cell apoptotic process
peptidyl-serine phosphorylation
angiotensin-activated signaling pathway
positive regulation of GTPase activity
protein autophosphorylation
regulation of neurotransmitter secretion
regulation of neuronal synaptic plasticity
positive regulation of NF-kappaB transcription factor activity
positive regulation of calcium ion transport
interferon-gamma-mediated signaling pathway
regulation of cellular response to heat
regulation of mitochondrial membrane permeability involved in apoptotic process
signal transduction
positive regulation of neuron projection development
regulation of skeletal muscle adaptation
positive regulation of phospholipase A2 activity
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
regulation of synapse structural plasticity
regulation of calcium ion transport
regulation of dendritic spine development
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
regulation of cell growth
response to hypoxia
regulation of the force of heart contraction
regulation of membrane depolarization
regulation of transcription from RNA polymerase II promoter
regulation of heart contraction
regulation of G2/M transition of mitotic cell cycle
positive regulation of cardiac muscle hypertrophy
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
positive regulation of smooth muscle cell migration
peptidyl-threonine phosphorylation
cellular potassium ion homeostasis
endoplasmic reticulum calcium ion homeostasis
positive regulation of Rac protein signal transduction
positive regulation of smooth muscle cell proliferation
protein oligomerization
relaxation of cardiac muscle
regulation of ryanodine-sensitive calcium-release channel activity
regulation of cellular localization
cell growth involved in cardiac muscle cell development
positive regulation of ERK1 and ERK2 cascade
cellular response to calcium ion
cardiac muscle cell contraction
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of histone deacetylase activity
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of relaxation of cardiac muscle
negative regulation of sodium ion transmembrane transport
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
negative regulation of sodium ion transmembrane transporter activity
protein dephosphorylation
nervous system development
insulin secretion
cell differentiation
phosphorylation
ionotropic glutamate receptor signaling pathway
inhibitory G-protein coupled receptor phosphorylation
regulation of synaptic transmission, cholinergic
response to cadmium ion
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of apoptotic signaling pathway
regulation of sodium ion transport
cardiac muscle contraction
response to oxidative stress
multicellular organism development
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