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Product Details
PA1-41150
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues V(499) R R G S G T P E A E A P R Q(513) of human CaMKIIb.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 50% glycerol
Contains
0.025% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2067933
Target Information
CAMK2B (CaMKII beta) is a serine/threonine kinase that plays a role in synaptic plasticity, synaptic vesicle mobilization and regulation of gene expression. As a dominant kinase in the central nervous system it may function in long term potentiation and neurotransmitter release. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca++/calmodulin-dependent protein kinase II beta subunit; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM-kinase II beta chain; CaMK II; caMK-II subunit beta; MGC29528; proline rich calmodulin-dependent protein kinase; β CaMKII; βCaMKII
Gene Aliases: CAM2; CAMK2; CAMK2B; Camk2d; CAMKB; Ck2b
UniProt ID: (Human) Q13554, (Rat) P08413, (Mouse) P28652
Entrez Gene ID: (Human) 816, (Rat) 24245, (Mouse) 12323
actin binding
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
calmodulin binding
ATP binding
protein kinase binding
protein homodimerization activity
phospholipase binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
protein phosphorylation
signal transduction
positive regulation of neuron projection development
regulation of skeletal muscle adaptation
positive regulation of phospholipase A2 activity
positive regulation of GTPase activity
protein autophosphorylation
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
regulation of synapse structural plasticity
regulation of calcium ion transport
interferon-gamma-mediated signaling pathway
regulation of dendritic spine development
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
regulation of cellular response to heat
G1/S transition of mitotic cell cycle
inhibitory G-protein coupled receptor phosphorylation
calcium ion transport
peptidyl-serine phosphorylation
regulation of synaptic transmission, cholinergic
response to cadmium ion
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of apoptotic signaling pathway
nervous system development
phosphorylation
cell differentiation
Performance Guarantee
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