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Invitrogen
CaMKII beta Polyclonal Antibody
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Product Details
PA5-70099
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of rat CaMKII beta
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Yeast: 93%; Zebrafish: 100%
Target Information
CAMK2B (CaMKII beta) is a serine/threonine kinase that plays a role in synaptic plasticity, synaptic vesicle mobilization and regulation of gene expression. As a dominant kinase in the central nervous system it may function in long term potentiation and neurotransmitter release. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca++/calmodulin-dependent protein kinase II beta subunit; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; caM-kinase II beta chain; caMK-II subunit beta; MGC29528; β CaMKII; βCaMKII
Gene Aliases: Camk2b; Ck2b
UniProt ID: (Rat) P08413
Entrez Gene ID: (Rat) 24245
G1/S transition of mitotic cell cycle
inhibitory G-protein coupled receptor phosphorylation
protein phosphorylation
calcium ion transport
positive regulation of neuron projection development
peptidyl-serine phosphorylation
regulation of synaptic transmission, cholinergic
positive regulation of phospholipase A2 activity
response to cadmium ion
protein autophosphorylation
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
positive regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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