Immunogen sequence: MDGSGMPKTM QSEETRVWHR RDGKWQNVHF HRSGSPTVPI KPPCIPNGKE NFSGGTSLWQ
CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Expression of CAMK2 delta is significantly increased in patients suffering from dilated cardiomyopathy.
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Protein Aliases: calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CaM-kinase II delta chain; CaMK-II delta subunit; caMK-II subunit delta; CAMKD
Gene Aliases: CAMK2D; CAMKD
UniProt ID: (Human) Q13557
Entrez Gene ID: (Human) 817
Molecular Function: non-receptor serine/threonine protein kinase