Invitrogen

CaMKII delta Polyclonal Antibody

View all (9) CaMKII delta antibodies

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CaMKII delta Antibody in Immunocytochemistry (ICC) — Immunocytochemical analysis of CaMKII delta in Hela cells using a CaMKII delta Polyclonal antibody (Product # PA5-85969)..

CaMKII delta Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of CaMKII delta of paraffin-embedded Human skeletal muscle tissue using a CaMKII-delta Polyclonal antibody (Product #PA5-85969).

CaMKII delta Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of CaMKII delta of paraffin-embedded Human brain tissue using a CaMKII-delta Polyclonal antibody (Product #PA5-85969).

CaMKII delta Antibody in Western Blot (WB) — Western blot analysis of CaMKII delta in K562 using a CaMKII delta Polyclonal antibody (Product # PA5-85969).

Product Details

Tested Applications

Dilution

Immunocytochemistry (ICC)

1:50

Immunofluorescence (IF)

1:50

Immunohistochemistry (IHC)

1:200

Western Blot (WB)

1:2,000

Product Specifications

Species Reactivity

Human, Mouse

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to Human CAMK2D aa 433-446

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.4, with 1% BSA, 40% Glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target Information

CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Expression of CAMK2 delta is significantly increased in patients suffering from dilated cardiomyopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CaM-kinase II delta chain; CaMK-II delta subunit; caMK-II subunit delta

Gene Aliases: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CaMK II; CAMK2D; CAMKD; Kiaa4163

UniProt ID: (Human) Q13557, (Mouse) Q6PHZ2

Entrez Gene ID: (Human) 817, (Mouse) 108058

Molecular Function: non-receptor serine/threonine protein kinase

G1/S transition of mitotic cell cycle MAPK cascade regulation of cell growth response to hypoxia regulation of the force of heart contraction regulation of membrane depolarization regulation of transcription from RNA polymerase II promoter protein phosphorylation calcium ion transport regulation of heart contraction regulation of G2/M transition of mitotic cell cycle positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of smooth muscle cell migration peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular potassium ion homeostasis endoplasmic reticulum calcium ion homeostasis positive regulation of Rac protein signal transduction positive regulation of GTPase activity protein autophosphorylation positive regulation of smooth muscle cell proliferation protein oligomerization relaxation of cardiac muscle regulation of ryanodine-sensitive calcium-release channel activity interferon-gamma-mediated signaling pathway regulation of cellular localization cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion cardiac muscle cell contraction regulation of heart rate by cardiac conduction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of cellular response to heat regulation of histone deacetylase activity regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of sodium ion transmembrane transporter activity regulation of sodium ion transport phosphorylation cardiac muscle contraction

Process(es)

protein serine/threonine kinase activity calmodulin-dependent protein kinase activity Ras guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding sodium channel inhibitor activity titin binding protein homodimerization activity ion channel binding nitric-oxide synthase binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups