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Product Details
13263-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CaMKIV Fusion Protein Ag3922 (1-302 aa encoded by BC025687)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLKVTVPSC SASSCSSVTA SAAPGTASLV PDYWIDGSNR DALSDFFEVE SELGRGATSI VYRCKQKGTQ KPYALKVLKK TVDKKIVRTE IGVLLRLSHP NIIKLKEIFE TPTEISLVLE LVTGGELFDR IVEKGYYSER DAADAVKQIL EAVAYLHENG IVHRDLKPEN LLYATPAPDA PLKIADFGLS KIVEHQVLMK TVCGTPGYCA PEILRGCAYG PEVDMWSVGI ITYILLCGFE PFYDERGDQF MFRRILNCEY YFISPWWDEV SLNAKDLVRK LIVLDPKKRL TTFQALQHPW VTG (1-302 aa encoded by BC025687)
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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