The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Voltage-dependent Ca2+ channelsmediate Ca2+ entryinto excitable cells in response tomembrane depolarization, and they are involved in a variety of Ca2+-dependent processes, includingmuscle contraction, hormone or neurotransmitter release and gene expression. Calciumchannels are highly diverse, multimeric complexescomposed of anα-1 subunit, an intracellular β-subunit, a disulfide linkedα-2/δ-subunit and a transmembrane γ-subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R-types. R-type Ca++ currentsinitiate a rapid synaptictransmission that isregulated through G proteins, SNARE proteins, and protein phosphorylation. R-type Ca++ channels may partially regulate the secretory processin chromaffin cells bymediating rapid secretoryresponses evoked byshort depolarizing pulses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BII; Brain calcium channel II; CACH6, CACNL1A6; CACNA1E; Calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, R type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, L type, alpha 1E subunit; RBE-II; RBE2; voltage gated calcium channel alpha1E subunit; voltage-dependent calcium channel alpha 1E subunit; voltage-dependent calcium channel alpha1-E subunit; Voltage-dependent R-type calcium channel subunit alpha-1E; voltage-gated calcium channel alpha subunit Cav2.3; Voltage-gated calcium channel subunit alpha Cav2.3
Gene Aliases: A430040I15; alpha1E; BII; CACH6; CACHA1E; CACNA1E; CACNL1A6; Cav2.3; Cchra1; gm139
UniProt ID: (Human) Q15878