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Immunogen sequence: TDWGPRFRK LAELYGASEG PAPLW (778-801 aa encoded by BC101048)
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cadherin; cadherin 20, type 2; cadherin 7; Cadherin-20; Cadherin-7
Gene Aliases: Cad20; CDH20; Cdh7; CDH7L3
UniProt ID: (Human) Q9HBT6, (Rat) Q5DWV1, (Mouse) Q9Z0M3
Entrez Gene ID: (Human) 28316, (Rat) 363948, (Mouse) 23836
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