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AbboMax

Cadherin (pan) Polyclonal Antibody

View all (11) Pan-cadherin antibodies

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Product Details

500-2364

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide of Pan Cadherin

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: Cardiac tissue

Cellular location: membrane, junctions.

Target Information

Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; Cadherin-N; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; cell-CAM 120/80; E-cadherin; E-cadherin 1; epididymis secretory sperm binding protein; Epithelial cadherin; N-cadherin; N-cadherin 1; Neural cadherin; Neural-cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; Retinal cadherin; unnamed protein product; Uvomorulin

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Gene Aliases: ACOGS; ADHD8; Arc-1; ARVD14; BCDS1; CAD4; CD324; CD325; CDH1; CDH2; CDH3; CDH4; CDHE; CDHN; CDHP; CDw325; ECAD; HJMD; LCAM; NCAD; PCAD; R-CAD; RCAD; UVO

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UniProt ID: (Human) P12830, (Human) P19022, (Human) P22223, (Human) P55283

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Entrez Gene ID: (Human) 999, (Human) 1000, (Human) 1001, (Human) 1002

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Function(s)
calcium ion binding protein binding beta-catenin binding ankyrin binding GTPase activating protein binding identical protein binding gamma-catenin binding cadherin binding metal ion binding cell adhesion molecule binding protein binding involved in cell-cell adhesion protein tyrosine kinase binding RNA binding enzyme binding protein kinase binding protein phosphatase binding alpha-catenin binding
Process(es)
cell morphogenesis desmosome assembly cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly response to xenobiotic stimulus response to toxic substance regulation of gene expression calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration pituitary gland development negative regulation of cell-cell adhesion negative regulation of cell migration negative regulation of axon extension neuron projection development cell junction assembly adherens junction organization positive regulation of protein import into nucleus cell-cell adhesion mediated by cadherin positive regulation of transcription, DNA-templated regulation of transport cellular response to lithium ion response to heparin cellular response to indole-3-methanol protein localization to plasma membrane cell-cell adhesion regulation of protein catabolic process at postsynapse, modulating synaptic transmission response to Gram-positive bacterium positive regulation of cellular protein localization heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules axon guidance positive regulation of axon extension axon extension type B pancreatic cell development glial cell differentiation neural crest cell development telencephalon development cerebral cortex development detection of muscle stretch positive regulation of MAPK cascade blood vessel morphogenesis brain morphogenesis homeostasis of number of cells striated muscle cell differentiation radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation negative regulation of canonical Wnt signaling pathway mesenchymal cell migration synaptic vesicle clustering neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering retina homeostasis visual perception positive regulation of gene expression positive regulation of keratinocyte proliferation hair cycle process negative regulation of transforming growth factor beta receptor signaling pathway keratinization positive regulation of monophenol monooxygenase activity positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of melanin biosynthetic process negative regulation of catagen positive regulation of canonical Wnt signaling pathway positive regulation of melanosome transport
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