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Invitrogen
Calbindin D28K Polyclonal Antibody
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FIGURE: 1 / 5
Calbindin D28K Antibody (PA5-142965) in IHC (P)
Immunohistochemistry analysis of Calbindin D28K in human kidney. Samples were incubated with Calbindin D28K polyclonal antibody (Product # PA5-142965) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-142965
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-KTFVDQYGQRDDGK (aa 59-72).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: Immunizing peptide overlaps EF hand 2, but not any calcium binding site.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Calbindin-D-28K (also termed vitamin D-dependent calcium-binding protein, or cholecalcin), is a highly conserved 28kDa calcium binding protein, with broad tissue distribution. It belongs, together with calmodulin, S-100, parvalbumin, troponin C and other proteins, to a family of low molecular weight calcium-binding proteins (CaBPs). These CaBPs have homologous primary structures, which contain conserved polypeptide folds of the EF-hand type for Ca2+ binding. Calbindin-D-28K is found predominantly in subpopulations of central and peripheral nervous system neurons, and in certain epithelial nervous system neurons, and in certain epithelial cells involved in Ca2+ transport such as distal tubular cells and cortical collecting tubules of the kidney, and in enteric neuroendocrine cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calbindin; calbindin 1, (28kD); calbindin 1, 28 kD; calbindin 1, 28kDa; calbindin 27; Calbindin D28; calbindin-D28k; cerebellar Ca-binding protein spot 35 protein; cerebellar Ca-binding protein, spot 35 protein; D-28K; retrovirus-like H primer binding sequence protein; RTVL-H protein; Spot 35 protein; unnamed protein product; Vitamin D-dependent calcium-binding protein, avian-type
Gene Aliases: CAB27; CaBP28K; CALB; CALB1; D-28K
UniProt ID: (Human) P05937, (Rat) P07171
Entrez Gene ID: (Human) 793, (Rat) 83839
learning or memory
short-term memory
long-term memory
locomotory behavior
retina layer formation
response to auditory stimulus
metanephric part of ureteric bud development
regulation of synaptic plasticity
calcium ion homeostasis
retina development in camera-type eye
metanephric collecting duct development
metanephric distal convoluted tubule development
metanephric connecting tubule development
cochlea development
regulation of presynaptic cytosolic calcium ion concentration
regulation of postsynaptic cytosolic calcium ion concentration
vitamin D metabolic process
regulation of cytosolic calcium ion concentration
cellular response to organic substance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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