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Invitrogen
Calcium Channel beta-4 Polyclonal Antibody
Product Details
PA1-12671
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, conjugated to KLH, corresponding to the rat calcium channel beta4 subunit.
Conjugate
Form
Liquid
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2069779
Product Specific Information
A suggested positive control for this product is rat brain lysate.
Target Information
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAB4; Calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207247; OTTHUMP00000207249; Voltage-dependent L-type calcium channel subunit beta-4
Gene Aliases: CAB4; CACNB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6
UniProt ID: (Human) O00305
Entrez Gene ID: (Human) 785
transport
cellular calcium ion homeostasis
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
neuromuscular junction development
adult walking behavior
gamma-aminobutyric acid secretion
neuronal action potential propagation
synaptic transmission, glutamatergic
cAMP metabolic process
spleen development
thymus development
Peyer's patch development
muscle fiber development
T cell receptor signaling pathway
detection of light stimulus involved in visual perception
membrane depolarization
cardiac conduction
calcium ion transmembrane transport
regulation of voltage-gated calcium channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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