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Invitrogen
Calcium Channel beta-4 Polyclonal Antibody
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FIGURE: 1 / 5
Calcium Channel beta-4 Antibody (PA5-27124) in ICC/IF
CACNB4 antibody [C3], C-term detects CACNB4 protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CACNB4 protein stained by CACNB4 antibody [C3], C-term (Product # PA5-27124) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
PA5-27124
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Cav beta 4. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, HepG2, A375, mouse cerebellum.
Predicted reactivity: Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAB4; Calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207247; OTTHUMP00000207249; unnamed protein product; Voltage-dependent L-type calcium channel subunit beta-4
Gene Aliases: 3110038O15Rik; CAB4; CACNB4; CACNLB4; Cchb4; EA5; EIG9; EJM; EJM4; EJM6; lh
UniProt ID: (Human) O00305, (Mouse) Q8R0S4
Entrez Gene ID: (Human) 785, (Mouse) 12298
voltage-gated calcium channel activity
calcium channel regulator activity
calcium channel activity
protein binding
protein kinase binding
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
voltage-gated ion channel activity
high voltage-gated calcium channel activity
voltage-gated ion channel
ion transport
calcium ion transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
neuromuscular junction development
adult walking behavior
negative regulation of cell proliferation
gamma-aminobutyric acid secretion
neuronal action potential propagation
ion transmembrane transport
synaptic transmission, glutamatergic
regulation of membrane potential
cAMP metabolic process
spleen development
thymus development
Peyer's patch development
T cell receptor signaling pathway
neurological system process
detection of light stimulus involved in visual perception
muscle cell development
calcium ion transmembrane transport
regulation of presynaptic cytosolic calcium ion concentration
positive regulation of protein localization to nucleolus
cellular response to leukemia inhibitory factor
negative regulation of G1/S transition of mitotic cell cycle
regulation of synaptic vesicle exocytosis
transport
cellular calcium ion homeostasis
T cell differentiation
regulation of ion transmembrane transport
muscle fiber development
synaptic transmission, GABAergic
regulation of voltage-gated calcium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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