Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Calcium Channel beta-4 Polyclonal Antibody
FIGURE: 1 / 5
Calcium Channel beta-4 Antibody (PA5-27124) in ICC/IF
CACNB4 antibody [C3], C-term detects CACNB4 protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CACNB4 protein stained by CACNB4 antibody [C3], C-term (Product # PA5-27124) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
PA5-27124
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 458 and 520 of Human CAB4
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2544600
Product Specific Information
Recommended positive controls: 293T, HepG2, A375, mouse cerebellum.
Predicted reactivity: Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CAB4; Calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207247; OTTHUMP00000207249; Voltage-dependent L-type calcium channel subunit beta-4
Gene Aliases: 3110038O15Rik; CAB4; CACNB4; CACNLB4; Cchb4; EA5; EIG9; EJM; EJM4; EJM6; lh
UniProt ID: (Human) O00305, (Mouse) Q8R0S4
Entrez Gene ID: (Human) 785, (Mouse) 12298
transport
cellular calcium ion homeostasis
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
neuromuscular junction development
adult walking behavior
gamma-aminobutyric acid secretion
neuronal action potential propagation
synaptic transmission, glutamatergic
cAMP metabolic process
spleen development
thymus development
Peyer's patch development
muscle fiber development
T cell receptor signaling pathway
detection of light stimulus involved in visual perception
membrane depolarization
cardiac conduction
calcium ion transmembrane transport
regulation of voltage-gated calcium channel activity
ion transport
calcium ion transport
T cell differentiation
regulation of ion transmembrane transport
regulation of membrane potential
neurological system process
synaptic transmission, GABAergic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support