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|Tested species reactivity||Human, Rat|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide from N-terminus of rat calcium sensing receptor|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.6, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine and mouse based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is placenta tissue.
The calcium sensing receptor (CaSR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Immunohistochemical Predictors of Bone Metastases in Breast Cancer Patients.
PA1-37213 was used in immunohistochemistry to evaluate the potential protein markers of bone metastases in breast cancer patients
|Winczura P,Sosińska-Mielcarek K,Duchnowska R,Badzio A,Lakomy J,Majewska H,Pęksa R,Pieczyńska B,Radecka B,Dębska-Szmich S,Adamowicz K,Biernat W,Jassem J||Pathology oncology research : POR (21:1229)||2015|
A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia.
PA1-37213 was used in western blot to identify novel loss-of-function Q459R mutation in the CASR gene and to study its effect on autosomal dominant familial hypocalciuric hypercalcemia.
|Lietman SA,Tenenbaum-Rakover Y,Jap TS,Yi-Chi W,De-Ming Y,Ding C,Kussiny N,Levine MA||The Journal of clinical endocrinology and metabolism (94:4372)||2009|
calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); CaSR antibody; extracellular calcium-sensing receptor; parathyroid Ca(2+)-sensing receptor 1; parathyroid Cell calcium-sensing receptor; parathyroid cell calcium-sensing receptor 1; Parathyroid Cell calcium-sensing receptor antibody.; PCaR1
CAR; CASR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1