Invitrogen

Calmodulin 1/2/3 Polyclonal Antibody

View all (5) Calmodulin 1/2/3 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-104261

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CALM1(Accession P0DP23), corresponding to amino acid residues V56-L106.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2853575

Product Specific Information

Antibody detects endogenous levels of total Calmodulin1/2/3.

Target Information

Calmodulin is a small, highly conserved calcium binding protein found in all eukaryotic cells. With the capacity to bind up to four calcium ions, this 17 kDa protein acts as an important intracellular receptor for regulatory calcium signals. As it binds calcium, calmodulin undergoes conformational changes which can increase its affinity for target proteins. It acts both directly, through interaction with key target enzymes, and indirectly, via specific kinases. Studies have found that calmodulin participates in the regulation of several biological processes including energy and biosynthetic metabolism, cell motility, exocytosis, cytoskeletal assembly, and intracellular modulation of both cAMP and calcium concentrations.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: calmodulin; Calmodulin 1 (phosphorylase kinase, delta); calmodulin 2 (phosphorylase kinase, delta); calmodulin 3 (phosphorylase kinase, delta); Calmodulin III; Calmodulin-1; Calmodulin-2; Calmodulin-3; caM; epididymis secretory protein Li 72; LP7057 protein; phosphorylase kinase delta; phosphorylase kinase subunit delta; phosphorylase kinase, delta subunit; prepro-calmodulin 1; prepro-calmodulin 2; prepro-calmodulin 3

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Gene Aliases: 1500001E21Rik; AI256814; AI327027; AI461935; AL024000; AL024017; CALM; CALM1; CALM2; CALM3; CALML2; CAM; CAM1; CAM2; CAM3; CaMA; CAMB; CAMC; CAMI; CAMII; CAMIII; CPVT4; DD132; HEL-S-72; LQT14; LQT15; PHKD; PHKD2; PHKD3; R75142; RNCAMIII

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UniProt ID: (Human) P0DP25, (Rat) P0DP31, (Mouse) P0DP28, (Mouse) Q498A3

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Entrez Gene ID: (Human) 801, (Human) 805, (Human) 808, (Rat) 24242, (Mouse) 12313, (Rat) 50663, (Mouse) 12314, (Rat) 24244, (Mouse) 12315

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Function(s)
Ras guanyl-nucleotide exchange factor activity calcium ion binding protein binding adenylate cyclase binding inositol-1,4,5-trisphosphate 3-kinase activity ligand-gated ion channel activity protein kinase binding protein domain specific binding nitric-oxide synthase regulator activity titin binding type 3 metabotropic glutamate receptor binding thioesterase binding N-terminal myristoylation domain binding phospholipase binding protein serine/threonine kinase activator activity phosphatidylinositol 3-kinase binding ion channel binding calcium-dependent protein binding nitric-oxide synthase binding protein phosphatase activator activity calcium channel regulator activity enzyme regulator activity protein N-terminus binding calmodulin-related
Process(es)
G2/M transition of mitotic cell cycle MAPK cascade response to amphetamine regulation of heart rate platelet degranulation detection of calcium ion glycogen catabolic process muscle contraction G-protein coupled receptor signaling pathway activation of adenylate cyclase activity Wnt signaling pathway, calcium modulating pathway positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion substantia nigra development regulation of rhodopsin mediated signaling pathway positive regulation of cyclic nucleotide metabolic process positive regulation of protein autophosphorylation regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity ion transmembrane transport positive regulation of protein dephosphorylation Fc-epsilon receptor signaling pathway positive regulation of DNA binding positive regulation of GTPase activity inositol phosphate metabolic process regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase activity positive regulation of cyclic-nucleotide phosphodiesterase activity response to corticosterone response to calcium ion regulation of cardiac muscle contraction negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of protein serine/threonine kinase activity regulation of high voltage-gated calcium channel activity regulation of cell communication by electrical coupling involved in cardiac conduction calcium-mediated signaling regulation of ryanodine-sensitive calcium-release channel activity regulation of store-operated calcium channel activity regulation of catalytic activity
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