Immunogen sequence: MADQLTEEQI AEFKEAFSLF RVRVLQGVRL SENVVNRMKE PSSPPPAPTS STFGLQDGNL RAPHKESTLP RSGSSGGQQP SGMKEGVKRY EQEHAAIQDK LFQVAKRERE AATKHSKASL PTGEGSISHE EQKSVRLARE LESREAELRR RDTFYKEQLE RIERKNAEMY KLSSEQFHEA ASKMESTIKP RRVEPVCSGL QAQILHCYRD RPHEVLLCSD LVKAYQRCVS AAHKG; Positive Samples: Rat testis; Cellular Location: Cytoplasm, cytoskeleton, spindle, spindle pole
Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
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Protein Aliases: calmodulin; Calmodulin III; Calmodulin-1; Calmodulin-2; Calmodulin-3; caM
Gene Aliases: Calm; Calm1; Calm2; Calm3; Cam; Cam1; Cam2; Cam3; CaMA; Camb; CamC; CaMI; CaMII; CaMIII; R75142; RNCAMIII