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Product Details
15803-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Calpain S2 Fusion Protein Ag8534 (5-248 aa encoded by BC005397)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KALLEGADR GLGEALGGLF GGGGQRREGG GRNIGGIVGG IVNFISEAAA AQYTPEPPPT QQHFTSVEAS ESEEVRRFRQ QFTQLAGPDM EVGATDLMNI LNKVLSKHKD LKTDGFSLDT CRSIVSVMDS DTTGKLGFEE FKYLWNNIKK WQCVYKQYDR DHSGSLGSSQ LRGALQAAGF QLNEQLYQMI VRRYANEDGD MDFNNFISCL VRLDAMFRAF KSLDRDRDGL IQVSIKEWLQ LTMYS (5-248 aa encoded by BC005397)
Target Information
The Calpain family of proteins are calcium-regulated thiol proteases which have broad endopeptidase activity throughout the body. Calpain small subunit 2, also known as CSS2 or CAPNS2, is a calcium-dependent protease that is expressed ubiquitously in the cytoplasm. Part of a heterodimer composed of a small subunit and a large subunit, CSS2 catalyzes proteolysis of various proteins involved in cytoskeletal remodeling and signal transduction. CSS2 also acts as a chaperone to the larger subunit, mediating its correct folding and conformation. When bound as a heterodimer, CSS2 is thought to keep the catalytic activity of the large subunit dormant. After binding calcium, CSS2 is released from the complex, thereby activating the large subunit and allowing CSS2 to translocate from the cytoplasm to the cell membrane. Defects in the gene encoding CSS2 result in incorrect calpain activity and retarded fetal development, suggesting that CSS2 expression is essential for proper growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium-dependent protease small subunit 2; Calpain small subunit 2; calpain, small subunit 2; CSS2
Gene Aliases: 2310005G05Rik; 30K-2; CAPNS2
UniProt ID: (Human) Q96L46, (Mouse) Q9D7J7
Entrez Gene ID: (Human) 84290, (Mouse) 69543, (Rat) 679870
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