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Proteintech
Calponin 1 Polyclonal Antibody
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Product Details
13938-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Calponin Fusion Protein Ag4989 (1-297 aa encoded by BC022015)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody raised against the full-length of human CNN1 may cross-react with CNN2 and CNN3.
Immunogen sequence: MSSAHFNRG PAYGLSAEVK NKLAQKYDHQ REQELREWIE GVTGRRIGNN FMDGLKDGII LCEFINKLQP GSVKKINEST QNWHQLENIG NFIKAITKYG VKPHDIFEAN DLFENTNHTQ VQSTLLALAS MAKTKGNKVN VGVKYAEKQE RKFEPGKLRE GRNIIGLQMG TNKFASQQGM TAYGTRRHLY DPKLGTDQPL DQATISLQMG TNKGASQAGM TAPGTKRQIF EPGLGMEHCD TLNVSLQMGS NKGASQRGMT VYGLPRQVYD PKYCLTPEYP ELGEPAHNHH AHNYYNSA (1-297 aa encoded by BC022015)
Target Information
Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Basic calponin; calponin 1, basic, smooth muscle; calponin 1, smooth muscle; Calponin H1, smooth muscle; Calponin-1; calponins, basic; epididymis secretory protein Li 14; unnamed protein product
Gene Aliases: CN; CNN1; CnnI; HEL-S-14; Sm-Calp; SMCC
UniProt ID: (Human) P51911, (Mouse) Q08091, (Rat) Q08290
Entrez Gene ID: (Human) 1264, (Mouse) 12797, (Rat) 65204
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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