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QED Bioscience

Calreticulin Polyclonal Antibody

View all (48) Calreticulin antibodies

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Product Details

56259-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:10,000
-
Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Guinea pig, Hamster, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Human calreticulin synthetic peptide conjugated to KLH.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.0 mg/mL

Storage buffer

whole serum

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Autoantigen RO; CABP3; CALBP; Calcium-binding protein 3; CALR; calrectulin; Calregulin; Calreticulin; calreticulin precursor; CRP55; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; Ro ribonucleoprotein autoantigen (Ro/SS-A) precursor; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin); unnamed protein product

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Gene Aliases: CALR; CALR1; Calregulin; cC1qR; CRP55; CRT; CRTC; ERp60; HACBP; HEL-S-99n; I79_008346; RO; SSA

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UniProt ID: (Pig) P28491, (Bovine) P52193, (Human) P27797, (Rabbit) P15253, (Chinese hamster) Q8K3H7, (Mouse) P14211, (Rat) P18418

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Entrez Gene ID: (Pig) 100381266, (Sheep) 101104396, (Rabbit) 100350417, (Chicken) 100859104, (Bovine) 281036, (Human) 811, (Rabbit) 100009050, (Dog) 476694, (Chinese hamster) 100689096, (Mouse) 12317, (Guinea pig) 100713922, (Rat) 64202

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Function(s)
mRNA binding integrin binding calcium ion binding carbohydrate binding ubiquitin protein ligase binding androgen receptor binding unfolded protein binding complement component C1q binding DNA binding RNA binding nuclear export signal receptor activity iron ion binding protein binding zinc ion binding peptide binding hormone binding protein binding involved in protein folding metal ion binding chaperone binding molecular sequestering activity glycoprotein binding poly(A) RNA binding chaperone
Process(es)
negative regulation of transcription from RNA polymerase II promoter peptide antigen assembly with MHC class I protein complex protein export from nucleus positive regulation of cell proliferation positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of translation cortical actin cytoskeleton organization negative regulation of intracellular steroid hormone receptor signaling pathway protein localization to nucleus regulation of meiotic nuclear division negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway positive regulation of phagocytosis protein stabilization negative regulation of cell cycle arrest cellular senescence positive regulation of substrate adhesion-dependent cell spreading negative regulation of trophoblast cell migration positive regulation of NIK/NF-kappaB signaling positive regulation of dendritic cell chemotaxis regulation of transcription, DNA-templated protein folding cellular calcium ion homeostasis spermatogenesis response to xenobiotic stimulus response to estradiol response to testosterone protein folding in endoplasmic reticulum ERAD pathway glucocorticoid receptor signaling pathway regulation of apoptotic process positive regulation of cell cycle negative regulation of transcription, DNA-templated sequestering of calcium ion protein maturation cardiac muscle cell differentiation cellular response to electrical stimulus cellular response to lithium ion cellular response to virus response to peptide response to glycoside response to biphenyl cell cycle arrest positive regulation of DNA replication chaperone-mediated protein folding response to organic substance response to drug cellular response to organic substance
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