This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Suggested positive control: antigen standard for CALR (transient overexpression lysate).
Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.
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Protein Aliases: Autoantigen RO; CABP3; CALBP; Calcium-binding protein 3; CALR; calrectulin; Calregulin; Calreticulin; CRP55; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; grp60; HACBP; Sicca syndrome antigen A (autoantigen Ro; calreticulin)
Gene Aliases: BOS_7422; CALR; Calregulin; cC1qR; CRP55; CRT; CRTC; ERp60; HACBP; HEL-S-99n; I79_008346; RO; SSA
Molecular Function: calcium-binding protein