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Calsequestrin 2 Polyclonal Antibody

Calsequestrin 2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

Calsequestrin 2 Antibody (18422-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed C2C12 cell using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Calsequestrin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Calsequestrin 2 Antibody in Western Blot (WB)

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Product Details

18422-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Calsequestrin 2 Fusion Protein Ag13246 (1-399 aa encoded by BC022288)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKRTHLFIV GIYFLSSCRA EEGLNFPTYD GKDRVVSLSE KNFKQVLKKY DLLCLYYHEP VSSDKVTQKQ FQLKEIVLEL VAQVLEHKAI GFVMVDAKKE AKLAKKLGFD EEGSLYILKG DRTIEFDGEF AADVLVEFLL DLIEDPVEII SSKLEVQAFE RIEDYIKLIG FFKSEDSEYY KAFEEAAEHF QPYIKFFATF DKGVAKKLSL KMNEVDFYEP FMDEPIAIPN KPYTEEELVE FVKEHQRPTL RRLRPEEMFE TWEDDLNGIH IVAFAEKSDP DGYEFLEILK QVARDNTDNP DLSILWIDPD DFPLLVAYWE KTFKIDLFRP QIGVVNVTDA DSVWMEIPDD DDLPTAEELE DWIEDVLSGK INTEDDDEDD DDDDNSDEED NDDSDDDDDE (1-399 aa encoded by BC022288)

Target Information

Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.

JCI insight

Blackwell DJ,Faggioni M,Wleklinski MJ,Gomez-Hurtado N,Venkataraman R,Gibbs CE,Baudenbacher FJ,Gong S,Fishman GI,Boyle PM,Pfeifer K,Knollmann BC

Tue Feb 08 00:00:00 UTC 2022

The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.

JCI insight

Blackwell DJ,Faggioni M,Wleklinski MJ,Gomez-Hurtado N,Venkataraman R,Gibbs CE,Baudenbacher FJ,Gong S,Fishman GI,Boyle PM,Pfeifer K,Knollmann BC

Tue Feb 08 00:00:00 UTC 2022

Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy.

JCI insight

Shi Y,Fan W,Xu M,Lin X,Zhao W,Yang Z

Tue Mar 22 00:00:00 UTC 2022

Fer1l6 is essential for the development of vertebrate muscle tissue in zebrafish.

Molecular biology of the cell

Bonventre JA,Holman C,Manchanda A,Codding SJ,Chau T,Huegel J,Barton C,Tanguay R,Johnson CP

Fri Feb 01 00:00:00 UTC 2019

Fer1l6 is essential for the development of vertebrate muscle tissue in zebrafish.

Molecular biology of the cell

Bonventre JA,Holman C,Manchanda A,Codding SJ,Chau T,Huegel J,Barton C,Tanguay R,Johnson CP

Fri Feb 01 00:00:00 UTC 2019

A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology.

Stem cell reports

Birket MJ,Raibaud S,Lettieri M,Adamson AD,Letang V,Cervello P,Redon N,Ret G,Viale S,Wang B,Biton B,Guillemot JC,Mikol V,Leonard JP,Hanley NA,Orsini C,Itier JM

Tue Aug 13 00:00:00 UTC 2019

SK4 K⁺ channels are therapeutic targets for the treatment of cardiac arrhythmias.

EMBO molecular medicine

Haron-Khun S,Weisbrod D,Bueno H,Yadin D,Behar J,Peretz A,Binah O,Hochhauser E,Eldar M,Yaniv Y,Arad M,Attali B

Sat Apr 01 00:00:00 UTC 2017

SK4 K⁺ channels are therapeutic targets for the treatment of cardiac arrhythmias.

EMBO molecular medicine

Haron-Khun S,Weisbrod D,Bueno H,Yadin D,Behar J,Peretz A,Binah O,Hochhauser E,Eldar M,Yaniv Y,Arad M,Attali B

Sat Apr 01 00:00:00 UTC 2017

Viral delivered gene therapy to treat catecholaminergic polymorphic ventricular tachycardia (CPVT2) in mouse models.

Heart rhythm

Kurtzwald-Josefson E,Yadin D,Harun-Khun S,Waldman M,Aravot D,Shainberg A,Eldar M,Hochhauser E,Arad M

Sat Jul 01 00:00:00 UTC 2017

Viral delivered gene therapy to treat catecholaminergic polymorphic ventricular tachycardia (CPVT2) in mouse models.

Heart rhythm

Kurtzwald-Josefson E,Yadin D,Harun-Khun S,Waldman M,Aravot D,Shainberg A,Eldar M,Hochhauser E,Arad M

Sat Jul 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: calsequestrin 2 (cardiac muscle); calsequestrin 2, fast-twitch, cardiac muscle; Calsequestrin, cardiac muscle isoform; Calsequestrin-2; cardiac calsequestrin; SR calcium binding protein

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Gene Aliases: AA033488; AW146219; cardCSQ; CASQ2; cCSQ; Csq2; ESTM52; PDIB2

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UniProt ID: (Human) O14958, (Mouse) O09161, (Rat) P51868

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Entrez Gene ID: (Human) 845, (Pig) 397436, (Mouse) 12373, (Rat) 29209

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Function(s)

calcium ion binding protein binding protein homodimerization activity calcium-dependent protein binding protein kinase C binding metal ion binding calcium-binding protein

Process(es)

regulation of heart rate detection of calcium ion striated muscle contraction regulation of cell communication by electrical coupling regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ion transmembrane transport negative regulation of potassium ion transport sarcomere organization sequestering of calcium ion protein polymerization cardiac muscle contraction regulation of membrane repolarization negative regulation of ryanodine-sensitive calcium-release channel activity cellular response to caffeine Purkinje myocyte to ventricular cardiac muscle cell signaling negative regulation of potassium ion transmembrane transporter activity regulation of cardiac conduction regulation of muscle contraction regulation of cardiac muscle cell contraction biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Calsequestrin 2 Polyclonal Antibody

Calsequestrin 2 Antibody (18422-1-AP) in ICC/IF

Product Details

18422-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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