Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MDLRQFLMC LSLCTAFALS KPTEKKDRVH HEPQLSDKVH NDAQSFDYDH DAFLGAEEAK TFDQLTPEES KERLGKIVSK IDGDKDGFVT VDELKDWIKF AQKRWIYEDV ERQWKGHDLN EDGLVSWEEY KNATYGYVLD DPDPDDGFNY KQMMVRDERR FKMADKDGDL IATKEEFTAF LHPEEYDYMK DIVVQETMED IDKNADGFID LEEYIGDMYS HDGNTDEPEW VKTEREQFVE FRDKNRDGKM DKEETKDWIL PSDYDHAEAE ARHLVYESDQ NKDGKLTKEE IVDKYDLFVG SQATDFGEAL VRHDEF (1-315 aa encoded by B C013383)
Caluminin is a 315 amino acid Ca2+-binding member of the CREC, EF-hand protein family. Calumenin is a secreted protein t hat contains six Ca2+-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca2+, Calumenin interacts with serum amyloid P component (SAP) and, together, they may play a role in the immunological defense system and participate in amyloidosis, the pathological formation of amyloid deposits in different types of tissues. Calumenin has an inhibitory effect on the vitamin K-dependent g-carboxylation system which converts vitamin K-dependent proteins to Gla-containing proteins. Calumenin may also be involved in the pathophysiology of thrombosis and/or wound healing by acting in an autocrine or paracrine manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calumenin; Crocalbin; crocalbin-like protein; IEF SSP 9302; multiple EF-hand protein
Gene Aliases: 9530075H20Rik; CALU
UniProt ID: (Human) O43852, (Mouse) O35887
Entrez Gene ID: (Human) 813, (Mouse) 12321
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