Invitrogen

Carabin Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

View all (5) Carabin antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Product Image Gallery

Carabin Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of Carabin in Hep G2 cells using a Carabin polyclonal antibody (Product # PA5-84823). The analysis shows localization to nuclear bodies.

Carabin Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of Carabin in human tonsil and cerebral cortex tissues using a Carabin polyclonal antibody (Product # PA5-84823). Corresponding RNA-seq data are presented for the same tissues.

Carabin Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of Carabin demonstrates antibody specificity. Immunohistochemical analysis of Carabin using anti-Carabin Polyclonal Antibody (Product #PA5-84823), shows significant staining of Carabin in tonsil and shows minimal or weak staining in cerebral cortex tissues. The relative expression levels of Carabin within each tissue is shown using RNA-Seq.

Product Details

PA5-84823

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TBC1D10C

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Anitgen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2791972

Product Specific Information

Immunogen sequence: DLVQPPELQD DSSSLGSDSE LSGPGPYRQA DRYGFIGGSS AEPGPGHPPA DLIRQREMKW VEM

Target Information

Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Carabin; TBC1 domain family member 10C; TBC1 domain family, member 10C

Gene Aliases: CARABIN; EPI64C; TBC1D10C

UniProt ID: (Human) Q8IV04

Entrez Gene ID: (Human) 374403

Molecular Function: GTPase-activating protein

Function(s)

intracellular protein transport regulation of vesicle fusion retrograde transport, endosome to Golgi negative regulation of B cell activation negative regulation of NFAT protein import into nucleus negative regulation of ERK1 and ERK2 cascade activation of GTPase activity regulation of cilium assembly

Process(es)

GTPase activator activity protein binding Rab GTPase binding