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Invitrogen
Cardiotin Monoclonal Antibody (R2G)
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Product Details
OMA1-06030
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Chicken,
Cat,
Goat,
Hamster,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat,
Xenopus,
Zebrafish
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
R2G
Immunogen
Total protein extract of chicken gizzard.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
OMA1-06030 detects cardiotin from mouse, rat, hamster, canine, monkey, pig, cat, rabbit, frog, goat, xenopus,feline and human cardiomyocytes.
OMA1-06030 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~300 kDa protein representing the cardiotin protein complex, as well as ~100 kDa and ~60 kDa bands representing the cardiotin subunits from rat heart extract.
The OMA1-06030 immunogen is total protein extract from chicken gizzard.
Target Information
Cardiotin is a recently discovered, high molecular weight protein complex (~300 kDa) located in the longitudinal SR of cardiomyocytes. The cardiotin complex exists as 60 kDa and 100 kDa subunits. Both subunits contain the same amino-terminal 14 amino-acid sequence, and show high homology to human skeletal muscle alpha-actin. The tetrameric configuration of the cardiotin protein complex suggests that it exists as a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. Immunofluorescence studies colocalize cardiotin with SERCA 2a ATPase in the longitudinal sarcoplasmic reticulum (SR), although cardiotin is not expressed in junctional SR with SERCA 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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