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Invitrogen
Caspase 2 Polyclonal Antibody
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FIGURE: 1 / 5
Caspase 2 Antibody (PA5-95537) in IHC (P)
Immunohistochemistry analysis of Caspase 2 in paraffin-embedded human colon cancer tissue. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with Caspase 2 polyclonal antibody (Product # PA5-95537) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-C... View More
Product Details
PA5-95537
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human Caspase-2 recombinant protein (Position: G170-T325).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human PANC-1 whole cell, human 22RV1 whole cell, human SGC-7901 whole cell. IHC: human colon cancer tissue, human lung cancer tissue, mouse intestine tissue, rat spleen tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Caspase 2 gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CASP-2; CASP2; caspase 2 apoptosis-related cysteine peptidase; Caspase-2; ICH-1 protease; ICH-1L; ICH-1L/1S; NEDD-2; Neural precursor cell expressed developmentally down-regulated protein 2; Protease ICH-1; protein phosphatase 1, regulatory subunit 57; unnamed protein product
Gene Aliases: CASP-2; CASP2; ICH-1; ICH1; MRT80; NEDD-2; NEDD2; PPP1R57
UniProt ID: (Human) P42575, (Mouse) P29594, (Rat) P55215
Entrez Gene ID: (Human) 835, (Mouse) 12366, (Rat) 64314
luteolysis
neural retina development
proteolysis
apoptotic process
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
protein processing
DNA damage response, signal transduction by p53 class mediator
ectopic germ cell programmed cell death
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of neuron apoptotic process
protein maturation
cellular response to mechanical stimulus
apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
execution phase of apoptosis
positive regulation of apoptotic signaling pathway
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
brain development
aging
programmed cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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