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|Tested species reactivity||Bovine, Dog, Hamster, Human, Mouse, Primate, Sheep, Pig, Rabbit, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant full length human caspase 3 protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5-10 µg/mL|
|Immunoprecipitation (IP)||10 µg/ml|
|Western Blot (WB)||2.5-5.0 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-16332 targets Caspase 3 in IHC (P), IP, and WB applications and shows reactivity with Bovine, Canine, Hamster, Human, mouse, Non-human primate, Ovine, Porcine, Rabbit, and Rat samples.
The PA5-16332 immunogen is recombinant full length human caspase 3 protein.
Caspase 3 is ubiquitously expressed and like other caspases is synthesized as an inactive (32kDa) proenzyme. Upon activation, Caspase 3 is cleaved at Asp28-Ser29 and Asp175-Ser176 thereby generating two subunits of 17kDa and 12kDa, respectively. Recent studies have implicated that Caspase 3 is associated with the induction of apoptosis. Activation of Caspase 3 occurs in response to variety of apoptotic inducers including Fas mediated apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
apopain; apoptosis-related cysteine protease; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP-32; CPP32beta; cysteine protease CPP32; IRP; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
A830040C14Rik; AC-3; Apopain; BOS_23762; CASP-3; CASP3; Caspase-3; CC3; CPP-32; CPP32; CPP32B; Lice; mldy; SCA-1; Yama