This Antibody was verified by IP Mass Spectrometry to ensure that the antibody binds to the antigen stated. View Details
PA5-16335 targets Caspase 3 in immunohistochemistry (paraffin), immunoprecipitation, and western blot applications and shows reactivity with Bovine, Canine, Hamster, Human, mouse, Non-human primate, Ovine, Porcine, Rabbit, and Rat samples.
The PA5-16335 immunogen is recombinant full length human caspase 3 protein.
Caspase 3 is ubiquitously expressed and like other caspases is synthesized as an inactive (32kDa) proenzyme. Upon activation, Caspase 3 is cleaved at Asp28-Ser29 and Asp175-Ser176 thereby generating two subunits of 17kDa and 12kDa, respectively. Recent studies have implicated that Caspase 3 is associated with the induction of apoptosis. Activation of Caspase 3 occurs in response to variety of apoptotic inducers including Fas mediated apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Apopain; apoptosis-related cysteine protease; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase-3; CPP-32; CPP32beta; Cysteine protease CPP32; IRP; LICE; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Gene Aliases: A830040C14Rik; AC-3; Apopain; BOS_23762; CASP-3; CASP3; Caspase-3; CC3; CPP-32; CPP32; CPP32B; Lice; mldy; SCA-1; Yama