Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Dog, Guinea pig (100%); Galago, Mouse, Rat, Ferret, Sheep, Bovine, Cat, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Armadillo (94%); Opossum, Platypus (88%); Turkey, Chicken (81%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.
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Protein Aliases: caveolae; caveolin 1, caveolae protein; caveolin 1, caveolae protein, 22kDa; Caveolin-1; cell growth-inhibiting protein 32; HGNC:1527; OTTHUMP00000196475; Vesicular integral-membrane protein VIP21
Gene Aliases: BSCL3; CAV; CAV1; CGL3; LCCNS; MSTP085; PPH3; VIP21
Molecular Function: scaffold/adaptor protein