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          • Primary Antibodies ›
          • Caveolin 1 Antibodies

          Exalpha

          Caveolin 1 Polyclonal Antibody

          View all (48) Caveolin 1 antibodies

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          Cite Caveolin 1 Polyclonal Antibody

          Additional Information:
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          Product Details

          X1863P

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1-5 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide derived from the human caveolin-1 beta isoform

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.5-2 mg/mL

          Amount

          100 µg

          Purification

          Ammonium sulfate precipitation

          Storage buffer

          PBS

          Contains

          0.08% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: caveolae; caveolin 1, caveolae protein, 22kDa; Caveolin-1; cell growth-inhibiting protein 32; GIG32; HGNC:1527; OTTHUMP00000196475; unnamed protein product

          View more View less

          Gene Aliases: BSCL3; CAV; CAV1; CGL3; LCCNS; MSTP085; PPH3; VIP21

          View more View less

          UniProt ID: (Human) Q03135

          View more View less

          Entrez Gene ID: (Human) 857

          View more View less

          Function(s)
          receptor binding patched binding protein binding oxysterol binding cholesterol binding peptidase activator activity enzyme binding protein kinase binding protein tyrosine kinase inhibitor activity protein binding, bridging small GTPase binding nitric-oxide synthase inhibitor activity identical protein binding ion channel binding macromolecular complex binding protein heterodimerization activity nitric-oxide synthase binding ATPase binding binding, bridging inward rectifier potassium channel inhibitor activity protein sequestering activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade angiogenesis vasculogenesis response to hypoxia endothelial cell proliferation negative regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway regulation of the force of heart contraction glandular epithelial cell differentiation response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process nitric oxide biosynthetic process calcium ion transport cellular calcium ion homeostasis regulation of smooth muscle contraction skeletal muscle tissue development lactation protein localization cell proliferation negative regulation of cell proliferation cellular response to starvation response to bacterium negative regulation of signal transduction positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression positive regulation of cholesterol efflux protein transport vesicle organization receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process cytokine-mediated signaling pathway lipid storage cell differentiation regulation of blood coagulation cholesterol transport positive regulation of cell migration negative regulation of BMP signaling pathway negative regulation of epithelial cell differentiation mammary gland development T cell costimulation negative regulation of protein ubiquitination positive regulation of protein ubiquitination receptor internalization maintenance of protein location in cell response to progesterone nitric oxide homeostasis toll-like receptor 4 signaling pathway regulation of toll-like receptor 4 signaling pathway insulin receptor internalization angiotensin-activated signaling pathway vasoconstriction cholesterol homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAPK cascade response to estrogen protein localization to plasma membrane raft negative regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction nitric oxide metabolic process negative regulation of JAK-STAT cascade muscle cell cellular homeostasis fibroblast proliferation negative regulation of fibroblast proliferation negative regulation of pinocytosis regulation of cytosolic calcium ion concentration response to calcium ion establishment of localization in cell membrane depolarization calcium ion homeostasis mammary gland involution canonical Wnt signaling pathway negative regulation of necroptotic process caveola assembly cellular response to misfolded protein cellular response to peptide hormone stimulus cellular response to hyperoxia cellular response to transforming growth factor beta stimulus basement membrane organization caveolin-mediated endocytosis regulation of heart rate by cardiac conduction negative regulation of canonical Wnt signaling pathway apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of ventricular cardiac muscle cell action potential positive regulation of cold-induced thermogenesis regulation of ruffle assembly negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction protein localization to basolateral plasma membrane positive regulation of gap junction assembly positive regulation of ERAD pathway regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.

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