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Invitrogen
Cdc14B Polyclonal Antibody
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FIGURE: 1 / 3
Cdc14B Antibody (34-8900) in ICC/IF
Immunofluorescent staining of U2OS or HeLa cells with Rb anti-CDC14B (green) (Product # 34-8900). DNA is labeled with DAPI (blue), anti-CDC14B is labeled with FITC (green), and anti-Tubulin is labeled with rhodamine (red). CDC14B appears as bright nuclear dots and midbodies of cells undergoing cytokinesis. Image courtesy of Dr. Catherine Regnard and Dr. Ulrike Grueneberg, Max Planck Institute for Biochemistry, Germany.
Product Details
34-8900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the N-terminal region of the human Cdc14B protein.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CDC14B is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CDC14 cell division cycle 14 homolog B; CDC14B; similar to Saccharomyces cerevisiae Cdc14p; CDC14Bpar; dual specific protein; Dual specificity protein phosphatase CDC14B; unnamed protein product
Gene Aliases: 2810432N10Rik; A530086E13Rik; AA472821; CDC14B; Cdc14B1; Cdc14B2; CDC14B3; hCDC14B
UniProt ID: (Human) O60729, (Mouse) Q6PFY9
Entrez Gene ID: (Human) 8555, (Mouse) 218294
microtubule cytoskeleton organization
DNA repair
protein dephosphorylation
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
regulation of exit from mitosis
positive regulation of cytokinesis
cilium morphogenesis
positive regulation of ubiquitin protein ligase activity
dephosphorylation
G2 DNA damage checkpoint
peptidyl-tyrosine dephosphorylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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