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Proteintech
Cdc20 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-10252
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cdc20 fusion protein Ag0295
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAQFAFESD LHSLLQLDAP IPNAPPARWQ RKAKEAAGPA PSPMRAANRS HSAGRTPGRT PGKSSSKVQT TPSKPGGDRY IPHRSAAQME VASFLLSKEN QPENSQTPTK KEHQKAWALN LNGFDVEEAK ILRLSGKPQN APEGYQNRLK VLYSQKATPG SSRKTCRYIP SLPDRILDAP EIRNDYYLNL VDWSSGNVLA VALDNSVYLW SA
Target Information
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC20 cell division cycle 20 homolog; cell division cycle 20 homolog; Cell division cycle protein 20 homolog; p55CDC
Gene Aliases: bA276H19.3; CDC20; CDC20A; p55CDC
UniProt ID: (Human) Q12834
Entrez Gene ID: (Human) 991
cell cycle
sister chromatid cohesion
mitotic nuclear division
positive regulation of cell proliferation
anaphase-promoting complex-dependent catabolic process
positive regulation of synaptic plasticity
regulation of meiotic nuclear division
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of dendrite development
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of synapse maturation
positive regulation of ubiquitin protein ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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