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Invitrogen
Cdc20 Polyclonal Antibody
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Product Details
PA5-102400
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDC20(Accession Q12834), corresponding to amino acid residues R44-L94.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CDC20.
Target Information
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC20 cell division cycle 20 homolog; cell cycle protein p55CDC; cell division cycle 20 homolog; Cell division cycle protein 20 homolog; fizzy homolog; mmCdc20; p55CDC; unnamed protein product
Gene Aliases: 2310042N09Rik; bA276H19.3; C87100; CDC20; CDC20A; OOMD14; OZEMA14; p55CDC
UniProt ID: (Human) Q12834, (Rat) Q62623, (Mouse) Q9JJ66
Entrez Gene ID: (Human) 991, (Rat) 64515, (Mouse) 107995
protein binding
anaphase-promoting complex binding
histone deacetylase binding
ubiquitin-protein transferase activator activity
protein binding, bridging involved in substrate recognition for ubiquitination
ubiquitin ligase activator activity
protein C-terminus binding
enzyme binding
ubiquitin-protein ligase
G2/M transition of mitotic cell cycle
mitotic sister chromatid cohesion
mitotic spindle assembly checkpoint
regulation of mitotic cell cycle
nervous system development
positive regulation of cell proliferation
protein ubiquitination
protein deubiquitination
cell differentiation
anaphase-promoting complex-dependent catabolic process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of synaptic plasticity
regulation of meiotic nuclear division
metaphase/anaphase transition of cell cycle
positive regulation of mitotic metaphase/anaphase transition
regulation of dendrite development
cell division
regulation of meiotic cell cycle
positive regulation of synapse maturation
mitotic spindle assembly
positive regulation of ubiquitin protein ligase activity
positive regulation of anaphase-promoting complex-dependent catabolic process
metaphase/anaphase transition of meiosis I
mitotic nuclear division
cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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