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Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (IHC) |
1:20-1:50 | - |
Immunocytochemistry (ICC/IF) |
0.25-2 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein corresponding to Human Cdc20 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2639559 |
Immunogen sequence: TPTKKEHQKA WALNLNGFDV EEAKILRLSG KPQNAPEGYQ NRLKVLYSQK ATPGSSRKTC RYIPSLPDRI LDAPEIRNDY
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 98%.
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDC20 cell division cycle 20 homolog; cell division cycle 20 homolog; Cell division cycle protein 20 homolog; p55CDC
Gene Aliases: bA276H19.3; CDC20; CDC20A; p55CDC
UniProt ID: (Human) Q12834
Entrez Gene ID: (Human) 991
Molecular Function:
ubiquitin-protein ligase
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