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Invitrogen
Cdc23 Polyclonal Antibody
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FIGURE: 1 / 4
Cdc23 Antibody (PA5-90232) in IHC (P)
Immunohistochemistry analysis of Cdc23 in paraffin-embedded human tonsil. Samples were incubated with Cdc23 Polyclonal antibody (Product # PA5-90232) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-90232
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CDC23 (NP_0046522)
Conjugate
Form
Liquid
Concentration
2.44 mg/mL
Amount
244 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HSSKWSAELA FSLPALPLAE LQPPPPITEE DAQDMDAYTL AKAYFDVKEY DRAAHFLHGC NSKKAYFLYM YSRYLSGEKK KDDETVDSLG PLEKGQVKNE A; Positive Samples: U-87MG, 293T, HeLa, Jurkat, HepG2, NIH/3T3, mouse liver, mouse kidney, rat liver
Target Information
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Anaphase-promoting complex subunit 8; APC8; CDC23 (cell division cycle 23, yeast, homolog); cell division cycle 23 homolog; Cell division cycle protein 23 homolog; Cyclosome subunit 8; tetratricopeptide protein; unnamed protein product
Gene Aliases: 6030435O18; ANAPC8; APC8; CDC23; CUT23; D18Ertd243e
UniProt ID: (Human) Q9UJX2, (Mouse) Q8BGZ4
Entrez Gene ID: (Human) 8697, (Mouse) 52563, (Rat) 291689
mitotic cell cycle
ubiquitin-dependent protein catabolic process
mitotic metaphase plate congression
metaphase/anaphase transition of mitotic cell cycle
regulation of exit from mitosis
regulation of mitotic cell cycle
protein ubiquitination
regulation of mitotic metaphase/anaphase transition
anaphase-promoting complex-dependent catabolic process
positive regulation of mitotic metaphase/anaphase transition
cell division
regulation of meiotic cell cycle
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein branched polyubiquitination
cell cycle
mitotic nuclear division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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