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Invitrogen
Cdc37 Polyclonal Antibody
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FIGURE: 1 / 3
Cdc37 Antibody (PA1-29131) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of NIH/3T3 (Lane 1), Neuro 2a (Lane 2), A549 (Lane 3) and PC-12 (Lane 4). The blot was probed with Anti-Cdc37 Polyclonal Antibody (Product # PA1-29131, 1 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 50 kDa band corresponding to CDC37 was observed across the cell lines tested.
Product Details
PA1-29131
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues 369-379 (Cys-PKAGNEKDVSA) from the C-terminus of MOUSE Cdc37
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
500 µg
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
RRID
Product Specific Information
PA1-29131 detects CDC37 from human and mouse samples.
PA1-29131 has been successfully used in immunoprecipitation and Western blot applications.
The PA1-29131 immunogen is: Synthetic peptide corresponding to residues 369-379 (Cys-PKAGNEKDVSA) from the C-terminus of MOUSE Cdc37
Target Information
In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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