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Invitrogen
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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PA1-29131 detects CDC37 from human and mouse samples.
PA1-29131 has been successfully used in immunoprecipitation and Western blot applications.
The PA1-29131 immunogen is: Synthetic peptide corresponding to residues 369-379 (Cys-PKAGNEKDVSA) from the C-terminus of MOUSE Cdc37
In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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