Immunogen sequence: MPAKTPIYLK AANNKKGKKF KLRDILSPDM ISPPLGDFRH TIHIGKEGQH DVFGDISFLQ GNYELLPGNQ EKAHLGQFPG HNEFFRANST SDSVFTETPS PVLKNAISLP TIGGSQALML PLLSPVTFNS KQESFGPAKL PRLSCEPVME EKAQEKSSLL ENGTVHQGDT SWGSSGSASQ SSQGRDSHSS SLSEQYPDWP AEDMFDHPTP CELIKGKTKS EESLSDLTGS LLSLQLDLGP SLLDEVLNVM DKNK; Positive Samples: 293T, K-562, NIH/3T3, Rat heart; Cellular Location: Cytoplasm, Endomembrane system, Peripheral membrane protein, cytoskeleton
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.
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Protein Aliases: Binder of Rho GTPases 2; CDC42 effector protein (Rho GTPase binding) 3; Cdc42 effector protein 3; CRIB-containing BORG2 protein; MSE55-related Cdc42-binding protein; MSE55-related protein
Gene Aliases: 3200001F04Rik; AA986861; BORG2; CDC42EP3; CEP3; UB1