Positive Control: Jurkat, HeLa, HeLa (10 mM Hydroxyurea treatment for 18 hr), Neuro2A, GL261, C8D30, BCL-1, Raw264.7, C2C12, PC-12, Rat2
Predicted Reactivity: Bovine (89%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
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Protein Aliases: CDC18(S.pombe); Cdc18-related protein; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6 homolog; HsCdc18; HsCDC6; p62(cdc6)
Gene Aliases: CDC18L; CDC6; HsCDC18; HsCDC6
Molecular Function: replication origin binding protein