Proteintech

Centrin 2 Polyclonal Antibody

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Antibody Testing Data (6)

Centrin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

Centrin 2 Antibody (15877-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 15877-1-AP) (Centrin 2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

15877-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Centrin 2 Fusion Protein Ag8638 (1-172 aa encoded by BC005334)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASNFKKAN MASSSQRKRM SPKPELTEEQ KQEIREAFDL FDADGTGTID VKELKVAMRA LGFEPKKEEI KKMISEIDKE GTGKMNFGDF LTVMTQKMSE KDTKEEILKA FKLFDDDETG KISFKNLKRV AKELGENLTD EELQEMIDEA DRDGDGEVSE QEFLRIMKKT SLY (1-172 aa encoded by BC005334)

Target Information

RNP2 a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The centrosomal recruitment of γ-tubulin and its microtubule nucleation activity is α-fodrin guided.

Cell cycle (Georgetown, Tex.)

Sreeja JS,Jyothy A,Nellikka RK,Ghorai S,Riya PA,James J,Sengupta S

Wed Feb 01 00:00:00 EST 2023

Mapping rhodopsin trafficking in rod photoreceptors with quantitative super-resolution microscopy.

bioRxiv : the preprint server for biology

Haggerty KN,Eshelman SC,Sexton LA,Frimpong E,Rogers LM,Agosto MA,Robichaux MA

Fri Apr 21 00:00:00 EDT 2023

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa.

Disease models & mechanisms

Robichaux MA,Nguyen V,Chan F,Kailasam L,He F,Wilson JH,Wensel TG

Sun May 01 00:00:00 EDT 2022

Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis.

The EMBO journal

Laporte MH,Bouhlel IB,Bertiaux E,Morrison CG,Giroud A,Borgers S,Azimzadeh J,Bornens M,Guichard P,Paoletti A,Hamel V

Wed Nov 02 00:00:00 EDT 2022

NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.

Cell research

Liu M,Zhang W,Li M,Feng J,Kuang W,Chen X,Yang F,Sun Q,Xu Z,Hua J,Yang C,Liu W,Shu Q,Yang Y,Zhou T,Xie S

Mon Nov 01 00:00:00 EDT 2021

Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.

Journal of cell science

Khouj EM,Prosser SL,Tada H,Chong WM,Liao JC,Sugasawa K,Morrison CG

Thu Oct 03 00:00:00 EDT 2019

Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.

Journal of cell science

Khouj EM,Prosser SL,Tada H,Chong WM,Liao JC,Sugasawa K,Morrison CG

Thu Oct 03 00:00:00 EDT 2019

Regulation of DNA demethylation by the XPC DNA repair complex in somatic and pluripotent stem cells.

Genes & development

Ho JJ,Cattoglio C,McSwiggen DT,Tjian R,Fong YW

Sat Apr 15 00:00:00 EDT 2017

Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Cattoglio C,Zhang ET,Grubisic I,Chiba K,Fong YW,Tjian R

Tue May 05 00:00:00 EDT 2015

Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Cattoglio C,Zhang ET,Grubisic I,Chiba K,Fong YW,Tjian R

Tue May 05 00:00:00 EDT 2015

The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells.

eLife

Fong YW,Ho JJ,Inouye C,Tjian R

Wed Nov 19 00:00:00 EST 2014

USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.

The Journal of clinical investigation

Zhang Y,Foreman O,Wigle DA,Kosari F,Vasmatzis G,Salisbury JL,van Deursen J,Galardy PJ

Sat Dec 01 00:00:00 EST 2012

USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.

The Journal of clinical investigation

Zhang Y,Foreman O,Wigle DA,Kosari F,Vasmatzis G,Salisbury JL,van Deursen J,Galardy PJ

Sat Dec 01 00:00:00 EST 2012

A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells.

Cell

Fong YW,Inouye C,Yamaguchi T,Cattoglio C,Grubisic I,Tjian R

Fri Sep 30 00:00:00 EDT 2011

A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells.

Cell

Fong YW,Inouye C,Yamaguchi T,Cattoglio C,Grubisic I,Tjian R

Fri Sep 30 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: Caltractin; caltractin (20kD calcium-binding protein); Caltractin isoform 1; caltractin, 20 kDa calcium binding protein; centrin 2; centrin, EF-hand protein, 2; Centrin-2; Centrin2; EF hand protein

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Gene Aliases: 1110034A02Rik; AI326150; CALT; caltractin; CEN2; CETN2

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UniProt ID: (Human) P41208, (Mouse) Q9R1K9

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Entrez Gene ID: (Human) 1069, (Rat) 84593, (Mouse) 26370

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Function(s)

calcium ion binding protein binding microtubule binding G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding metal ion binding calmodulin-related

Process(es)

G2/M transition of mitotic cell cycle nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair nucleotide-excision repair, preincision complex assembly mitotic nuclear division centriole replication spermatogenesis protein sumoylation regulation of cytokinesis cell division global genome nucleotide-excision repair DNA repair cellular response to DNA damage stimulus cell cycle

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Centrin 2 Polyclonal Antibody

Centrin 2 Antibody (15877-1-AP) in IHC (P)

Product Details

15877-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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