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Invitrogen
Chemerin Polyclonal Antibody
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FIGURE: 1 / 2
Chemerin Antibody (PA5-47299) in Neu
Neutralization of Chemerin in BaF3 mouse pro‚B cell line transfected with human Chem R23. Samples were incubated in Chemerin polyclonal antibody (Product # PA5-47299). Recombinant Mouse Chemerin chemoattracts the BaF3 mouse pro‚B cell line transfected with human Chem R23 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Mouse Chemerin (100 ng/mL) is neutralized (green line) by increasing concentrations of Goat Ant... View More
Product Details
PA5-47299
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse Chemerin Thr17-Ser156
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human Chemerin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs). Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted. TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles and endothelial cells as well as in pancreas, spleen and intestine. TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids. TIG2 is a secreted protein that is mainly expressed in epidermis, hair follicles and endothelial cells. TIG2 is inhibited in psoriatic lesions and is activated by tazarotene in skin rafts and in epidermis of psoriatic lesions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chemerin; Retinoic acid receptor responder protein 2; TIG-2; TIG2HP10433
Gene Aliases: 0610007L05Rik; AI303516; Rarres2
UniProt ID: (Mouse) Q9DD06
Entrez Gene ID: (Mouse) 71660
retinoid metabolic process
positive regulation of protein phosphorylation
chemotaxis
defense response
inflammatory response
positive regulation of macrophage chemotaxis
cell differentiation
positive regulation of fat cell differentiation
embryonic digestive tract development
brown fat cell differentiation
positive regulation of chemotaxis
regulation of lipid catabolic process
positive regulation of glucose import in response to insulin stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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