Proteintech

Chromogranin A Polyclonal Antibody

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Chromogranin A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human pancreas tissue slide using 10529-1-AP ( Chromogranin A antibody) at dilution of 1:1600 (under 10x lens).

Chromogranin A Antibody in Western Blot (WB) — PC-12 cells were subjected to SDS PAGE followed by western blot with 10529-1-AP (Chromogranin A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

Tested Applications

Dilution

Immunohistochemistry (Paraffin) (IHC (P))

1:400-1:1600

Western Blot (WB)

1:500-1:2000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Chromogranin A Fusion Protein Ag0807

Conjugate

Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Target Information

Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AL-11; AL26; Beta-granin; betagranin (N-terminal fragment of chromogranin A); Catestatin; CGA; CHGA; chromofungin; Chromogranin A; Chromogranin-A; EA-92; ER-37; ES-43; GE-25; GR-44; GV-19; LF-19; p-Glu serpinin precursor; Pancreastatin; parathyroid secretory protein 1; Pituitary secretory protein I; Serpinin; Serpinin-RRG; SL21; SP I; SP-I; SS-18; Vasostatin I; Vasostatin I Vasostatin 2; Vasostatin II; Vasostatin-1; Vasostatin-2; WA-8; WE-14

Gene Aliases: CGA; CHGA; ChrA

UniProt ID: (Human) P10645, (Mouse) P26339

Entrez Gene ID: (Human) 1113, (Rat) 24258, (Mouse) 12652

Molecular Function: peptide hormone signaling molecule