Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
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Protein Aliases: AL-11; AL26; Beta-granin; betagranin (N-terminal fragment of chromogranin A); Catestatin; CGA; CHGA; chromofungin; Chromogranin A; Chromogranin-A; EA-92; ER-37; ES-43; GE-25; GR-44; GV-19; LF-19; p-Glu serpinin precursor; Pancreastatin; parathyroid secretory protein 1; Pituitary secretory protein I; Serpinin; Serpinin-RRG; SL21; SP I; SP-I; SS-18; Vasostatin I; Vasostatin I Vasostatin 2; Vasostatin II; Vasostatin-1; Vasostatin-2; WA-8; WE-14
Gene Aliases: CGA; CHGA; ChrA