Invitrogen

Claudin 1 Polyclonal Antibody (MH25)

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

40 Published Figures

137 References

View all (18) Claudin 1 antibodies

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Claudin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of Claudin-1 showing staining in the membrane and weak cytoplasm staining of paraffin-embedded human liver tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Claudin-1 Rabbit Polyclonal Antibody (Product # 71-7800) diluted in 3% BSA-PBS at a dilution of 1:20 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.

Claudin 1 Antibody in Immunohistochemistry (IHC) — Immunofluorescent staining of rat small intestine using Rb anti-Claudin-1 (Product # 71-7800).

Claudin 1 Antibody in Western Blot (WB) — Western blot analysis using Rabbit anti-Claudin-1 Polyclonal Antibody in: Lane 1: Rat liver. Lane 2: Rat kidney. Lane 3: MDCK cells. Lane 4: Caco-2 cells. Lane 5: Mouse hepatocytes (Product # 71-7800).

Claudin 1 Antibody — Fig. 7. EGFR signaling disrupts TJ barrier function in epidermal keratinocytes. A : validation of microarray expression profiles of genes encoding TJ proteins ( n = 3-4). Results are expressed relative to values obtained in samples grown to 50% confluent cell density without EGF following normalization to values of TUBA1C . +Comparison between the untreated samples (confluent cell density effect). *Comparison between control and EGF at 100% confluent cell density. * P < 0.0253 (cut-off P value after Sidak-Bonferroni correction), ** P < 0.01, + P < 0.0253 (cut-off P value after Sidak-Bonferroni correction), ++ P < 0.01, +++ P < 0.001 by Student's t -test. B : densitometric measurements of junctional protein immunoblots for CLDN1 and TJP1 at the 96 h time point. ACTB is a loading control ( n = 3). NHEKs were grown to 100% confluent cell density before switching to basal medium with or without EGF (10 ng/ml) in the presence of 1.8 mM Ca 2+ . The medium was replaced with fresh basal medium containing the same treatments after 24 h. Cell lysates were prepared 72 h after the last medium change. Student's t -test was used to evaluate statistical significance (* P < 0.05). C : indirect immunofluorescence of CLDN1 and TJP1 in the presence or absence of EGF ( n = 3) at the 96 h time point. NHEKs were grown as described in B . Representative immunofluorescent micrographs of the control and EGF (10 ng/ml) treated monolayers are shown. Scale bar, 50 mum. Student's t -test was used to eval {TM}

Claudin 1 Antibody in Immunocytochemistry (ICC/IF) — FIGURE 2 Internalization of GFP S. aureus by Normal Human Epidermal Keratinocytes (NHEK). (A) Representative Amnis (r) Image Stream Analysis of NHEK co-cultured with 10 7 CFU/mL FITC LiSA for 1 h at 37degC, then treated for 30 min with 2% penicillin/streptomycin (P/S) to eliminate extracellular bacteria and cultured for a further 4 h prior to staining and analysis. Red stain: Alexa Fluor (r) 647 mouse anti-human cytokeratin 14/15/16/19. Green stain: FITC S. aureus. (B) Representative confocal microscopy 2D image of NHEK after co-culture with 10 7 CFU/mL GFP S. aureus for 1 h at 37degC. (C) Representative immunofluorescent staining of healthy human skin explant after 3 h infection with GFP S. aureus (10 7 CFU/mL) at 37degC. Red: anti-rabbit claudin-1 antibody. Green: GFP S. aureus. Yellow box (left panel) highlights area of right panel magnified. All data are representative of three independent experiments. Images taken at 40x magnification. Scale bars represent 100 mum.

Claudin 1 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF) — Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot and Immunocytochemistry

Claudin 1 Antibody in Western Blot, Immunohistochemistry (Frozen) (WB, IHC (F)) — Fig. 1 Intestinal barrier was destroyed in NEC patients and mice. a Representative sections from ileac tissue of Ctrl or NEC patients stained with anti-claudin-1, anti-occludin, and anti-ZO-1 antibodies. Neonatal intestinal atresia patients were used as controls. b Statistical analysis of the average optical density of immunohistochemical staining images of ( a ) (n = 5 per group). c and d Western blot analysis of claudin-1, occludin, and ZO-1 protein levels in small intestinal epithelial cells of NEC mice and relative gray calculation (n = 5 ~ 6 per group, representative data from four independent experiments). e The concentration of FITC-dextran 4 kDa (FD4) in the serum of Ctrl or NEC mice. Ctrl, dam-fed, n = 5 ~ 6 per group. Four independent experiments were performed. Data are shown as mean values +- SD. Statistical analyses were performed with Student's two-tailed unpaired t -test. * p < 0.05; ** p < 0.01; n.s., not significant. Scale bars represent 20 mum in ( a )

Claudin 1 Antibody in Immunohistochemistry (Frozen) (IHC (F)) — 4 Figure Betaine increases tight junction protein expression in human organ-cultured skin. (a) Claudin-1, claudin-4 and occludin immunofluorescence in ex vivo human skin cultured for 72 h under control conditions, in the presence of 35 mmol L -1 betaine, 10 mumol L -1 N -(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide ( BPDBA ), and both 10 mumol L -1 BPDBA and 35 mmol L -1 betaine. (b) Quantification of fluorescence intensity showed that the presence of BPDBA mitigated the increase in expression of all three tight junction proteins caused by betaine. (c) Claudin-1, claudin-4 and occludin gene expression was not affected by the presence of betaine. Data are presented as the mean +- SEM , two-way anova , n = 7. Bars = 50 mum. SC , stratum corneum.

Claudin 1 Antibody in Western Blot, Immunohistochemistry (WB, IHC) — Fig. 6 PXR protected barrier function from LPS damage. a TEER changes in Caco-2 cell monolayers treated with LPS for 24 or 48 h. b and c Western blot analysis of claudin-1, occludin, and ZO-1 protein levels in Caco-2 cells treated with LPS (n = 4 per group, representative data from three independent experiments). d Western blot analysis of PXR in Caco-2 treated with LPS. e Confirmation of PXR overexpression by Western blot. f and g Western blot analysis of the components of tight junctions (Claudin-1, Occludin, and ZO-1) in Caco-2 cells treated with LPS for 48 h (n = 4 per group, representative data from three independent experiments). h FD4 flux of basolateral medium was measured after Caco-2 cells were treated with LPS or not treated for 48 h (n = 5 per group, representative data from four independent experiments). Data are expressed as mean values +- SD. Statistical analyses were performed with Student's two-tailed unpaired t -test in ( c and g ), * p < 0.05; ** p < 0.01; n.s., not significant; TEER, transepithelial electrical resistance; FD4, FITC-dextran 4 kDa

Product Details

71-7800

Applications	Tested Dilution	Publications
Western Blot (WB)	1-2 µg/mL	View 57 publications 57 publications
Immunohistochemistry (IHC)	-	View 23 publications 23 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:10-1:100	View 5 publications 5 publications
Immunohistochemistry (Frozen) (IHC (F))	-	View 5 publications 5 publications
Immunocytochemistry (ICC/IF)	-	View 39 publications 39 publications
ELISA (ELISA)	0.1-1.0 µg/mL	-
Immunoprecipitation (IP)	-	View 4 publications 4 publications
Miscellaneous PubMed (Misc)	-	View 4 publications 4 publications

Product Specifications
Species Reactivity	Dog, Human, Mouse, Rat
Published species	Avian, Bovine, Dog, Fish, Human, Mouse, Rabbit, Rat, Tag, Virus
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Clone	MH25
Immunogen	A synthetic peptide derived from the C-terminus of the human/mouse Claudin-1 protein. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.25 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.4
Contains	0.1% sodium azide
Storage conditions	-20°C
RRID	AB_2533997

Product Specific Information

This antibody reacts with the ~ 22 kDa Claudin-1 protein. Reactivity was confirmed by western blotting and immunofluorescence. Positive controls include MDCK cells (dog), Caco-2cells (human), mouse liver, rat liver, and rat kidney.

NOTE: This antibody strongly cross reacts with the Claudin-3 protein. It has been observed in western blotting inhibition studies using Caco-2 cell lysates, that this antibody is inhibited by addition of Claudin-3 peptide. For a Claudin-1 specific antibody that does not cross-react with Claudin-3, please order Cat. No. 519000 (Rb x Claudin-1) instead.

Target Information

Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus.

Scientific reports

Crakes KR,Pires J,Quach N,Ellis-Reis RE,Greathouse R,Chittum KA,Steiner JM,Pesavento P,Marks SL,Dandekar S,Gilor C

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry (Paraffin)

Tue Jun 29 00:00:00 EDT 2021

Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus.

Scientific reports

Crakes KR,Pires J,Quach N,Ellis-Reis RE,Greathouse R,Chittum KA,Steiner JM,Pesavento P,Marks SL,Dandekar S,Gilor C

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry (Paraffin)

Tue Jun 29 00:00:00 EDT 2021

Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation.

Cellular and molecular gastroenterology and hepatology

Xing T,Benderman LJ,Sabu S,Parker J,Yang J,Lu Q,Ding L,Chen YH

71-7800 was used in Western Blotting to show that Cldn7 is indispensable in controlling Wnt/β-catenin signaling-dependent intestinal epithelial stem cell survival, self-renewal, and cell differentiation.

Mon May 10 00:00:00 EDT 2021

Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic Inflammation.

Cellular and molecular gastroenterology and hepatology

Koumangoye R,Omer S,Kabeer MH,Delpire E

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Wed May 05 00:00:00 EDT 2021

oprC Impairs Host Defense by Increasing the Quorum-Sensing-Mediated Virulence of Pseudomonas aeruginosa.

Frontiers in immunology

Gao P,Guo K,Pu Q,Wang Z,Lin P,Qin S,Khan N,Hur J,Liang H,Wu M

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Mon Apr 12 00:00:00 EDT 2021

oprC Impairs Host Defense by Increasing the Quorum-Sensing-Mediated Virulence of Pseudomonas aeruginosa.

Frontiers in immunology

Gao P,Guo K,Pu Q,Wang Z,Lin P,Qin S,Khan N,Hur J,Liang H,Wu M

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Mon Apr 12 00:00:00 EDT 2021

Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.

The British journal of dermatology

El-Chami C,Foster AR,Johnson C,Clausen RP,Cornwell P,Haslam IS,Steward MC,Watson REB,Young HS,O'Neill CA

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Mon Mar 01 00:00:00 EST 2021

Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.

The British journal of dermatology

El-Chami C,Foster AR,Johnson C,Clausen RP,Cornwell P,Haslam IS,Steward MC,Watson REB,Young HS,O'Neill CA

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Mon Mar 01 00:00:00 EST 2021

Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.

The British journal of dermatology

El-Chami C,Foster AR,Johnson C,Clausen RP,Cornwell P,Haslam IS,Steward MC,Watson REB,Young HS,O'Neill CA

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Mon Mar 01 00:00:00 EST 2021

Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.

The British journal of dermatology

El-Chami C,Foster AR,Johnson C,Clausen RP,Cornwell P,Haslam IS,Steward MC,Watson REB,Young HS,O'Neill CA

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Mon Mar 01 00:00:00 EST 2021

Impaired Airway Epithelial Barrier Integrity in Response to Stenotrophomonas maltophilia Proteases, Novel Insights Using Cystic Fibrosis Bronchial Epithelial Cell Secretomics.

Frontiers in immunology

Molloy K,Cagney G,Dillon ET,Wynne K,Greene CM,McElvaney NG

71-7800 was used in Western Blot to demonstrate destruction of the CFBE41o- TJC provide a novel insight regarding the virulence of S. maltophilia and may explain the possible injurious effects of this bacterium on the CF bronchial epithelium and the pathogenic mechanism leading to lethal pulmonary hemorrhage.

Fri Feb 19 00:00:00 EST 2021

Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway.

Cell & bioscience

Zhao X,Zhou J,Liang W,Sheng Q,Lu L,Chen T,Chen J,Tan K,Lv Z

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Tue Jan 19 00:00:00 EST 2021

Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway.

Cell & bioscience

Zhao X,Zhou J,Liang W,Sheng Q,Lu L,Chen T,Chen J,Tan K,Lv Z

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Tue Jan 19 00:00:00 EST 2021

Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway.

Cell & bioscience

Zhao X,Zhou J,Liang W,Sheng Q,Lu L,Chen T,Chen J,Tan K,Lv Z

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Tue Jan 19 00:00:00 EST 2021

Astragalus mongholicus Bunge and Panax Notoginseng Formula (A&P) Combined With Bifidobacterium Contribute a Renoprotective Effect in Chronic Kidney Disease Through Inhibiting Macrophage Inflammatory Response in Kidney and Intestine.

Frontiers in physiology

Rui-Zhi T,Hui D,Jian-Chun L,Xia Z,Xiao-Jia W,Dan W,Jun-Ming F,Li W

71-7800 was used in Western Blotting to explore the role of A&P and Bifidobacterium combination treatment in regulation of inflammatory response of macrophage in kidney and intestine of CKD mouse, as well as the potential molecular mechanism.

Fri Dec 18 00:00:00 EST 2020

RAS-mediated suppression of PAR3 and its effects on SCC initiation and tissue architecture occur independently of hyperplasia.

Journal of cell science

Ling J,Sckaff M,Tiwari M,Chen Y,Li J,Jones J,Sen GL

71-7800 was used in Immunohistochemistry (Frozen) to develop an inducible model of human squamous cell carcinoma to demonstrate the role of RAS in tumorigenic epithelial disorganization.

Mon Dec 07 00:00:00 EST 2020

Phosphorylation and dephosphorylation of Ser852 and Ser889 control the clustering, localization and function of PAR3.

Journal of cell science

Yamashita K,Mizuno K,Furukawa K,Hirose H,Sakurai N,Masuda-Hirata M,Amano Y,Hirose T,Suzuki A,Ohno S

71-7800 was used in Immunocytochemistry to demonstrate that unphosphorylatable forms of PAR3 exhibited a low molecular turnover and failed to coordinate rapid reconstruction of the tight junction, supporting that both the phosphorylated and dephosphorylated states are essential for the functional integrity of PAR3.

Mon Nov 30 00:00:00 EST 2020

Tissue-scale tensional homeostasis in skin regulates structure and physiological function.

Communications biology

Kimura S,Tsuchiya A,Ogawa M,Ono M,Suda N,Sekimoto K,Takeo M,Tsuji T

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry (Paraffin)

Fri Oct 30 00:00:00 EDT 2020

Tissue-scale tensional homeostasis in skin regulates structure and physiological function.

Communications biology

Kimura S,Tsuchiya A,Ogawa M,Ono M,Suda N,Sekimoto K,Takeo M,Tsuji T

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry (Paraffin)

Fri Oct 30 00:00:00 EDT 2020

Geniposide and Chlorogenic Acid Combination Ameliorates Non-alcoholic Steatohepatitis Involving the Protection on the Gut Barrier Function in Mouse Induced by High-Fat Diet.

Frontiers in pharmacology

Peng JH,Leng J,Tian HJ,Yang T,Fang Y,Feng Q,Zhao Y,Hu YY

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2020

Intestinal vitamin D receptor signaling ameliorates dextran sulfate sodium-induced colitis by suppressing necroptosis of intestinal epithelial cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Shi Y,Cui X,Sun Y,Zhao Q,Liu T

71-7800 was used in Western Blotting to offer some theoretical basis for a novel treatment of IBD in clinical practice.

Thu Oct 01 00:00:00 EDT 2020

Staphylococcus aureus Internalized by Skin Keratinocytes Evade Antibiotic Killing.

Frontiers in microbiology

Al Kindi A,Alkahtani AM,Nalubega M,El-Chami C,O'Neill C,Arkwright PD,Pennock JL

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunocytochemistry

Wed Sep 30 00:00:00 EDT 2020

The Histone Demethylase JMJD1C Regulates CAMKK2-AMPK Signaling to Participate in Cardiac Hypertrophy.

Frontiers in physiology

Yu S,Li Y,Zhao H,Wang Q,Chen P

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Mon Sep 28 00:00:00 EDT 2020

Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis.

Foods (Basel, Switzerland)

Shin MY,Yong CC,Oh S

71-7800 was used in Immunohistochemistry to investigate the regulatory effects of L. brevis Bmb6 on he tight junction (TJ) barrier to ameliorate colitis-symptoms.

Thu Jul 02 00:00:00 EDT 2020

Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis.

Foods (Basel, Switzerland)

Shin MY,Yong CC,Oh S

71-7800 was used in Immunohistochemistry to investigate the regulatory effects of L. brevis Bmb6 on he tight junction (TJ) barrier to ameliorate colitis-symptoms.

Thu Jul 02 00:00:00 EDT 2020

Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis.

Foods (Basel, Switzerland)

Shin MY,Yong CC,Oh S

71-7800 was used in Immunohistochemistry to investigate the regulatory effects of L. brevis Bmb6 on he tight junction (TJ) barrier to ameliorate colitis-symptoms.

Thu Jul 02 00:00:00 EDT 2020

Toxicological effects of bioactive peptide fractions obtained from Bothrops jararaca snake venom on the structure and function of mouse seminiferous epithelium.

The journal of venomous animals and toxins including tropical diseases

Alberto-Silva C,Franzin CS,Gilio JM,Bonfim RS,Querobino SM

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Mon Jun 22 00:00:00 EDT 2020

Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.

Cell death & disease

Shi Y,Liu Z,Cui X,Zhao Q,Liu T

71-7800 was used in Western Blotting to identify that intestinal vitamin D receptor knockout protected against oxazolone-induced colitis in mice by blocking Th2 cell response and reducing the function of intestinal invariant natural killer T cells.

Mon Jun 15 00:00:00 EDT 2020

Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins.

Cells

Wu CJ,Lu M,Feng X,Nakato G,Udey MC

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Tue Apr 21 00:00:00 EDT 2020

Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins.

Cells

Wu CJ,Lu M,Feng X,Nakato G,Udey MC

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Tue Apr 21 00:00:00 EDT 2020

The Differentiation-Associated Keratinocyte Protein Cornifelin Contributes to Cell-Cell Adhesion of Epidermal and Mucosal Keratinocytes.

The Journal of investigative dermatology

Wagner T,Beer L,Gschwandtner M,Eckhart L,Kalinina P,Laggner M,Ellinger A,Gruber R,Kuchler U,Golabi B,Tschachler E,Mildner M

71-7800 was used in Western Blotting to indicate that CNFN is a structural component of the cell adhesion system of differentiated KCs in both epidermis and oral mucosa.

Fri Nov 01 00:00:00 EDT 2019

Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile-Young Adult Rats.

Microorganisms

Tulyeu J,Kumagai H,Jimbo E,Watanabe S,Yokoyama K,Cui L,Osaka H,Mieno M,Yamagata T

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Wed Oct 16 00:00:00 EDT 2019

Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis.

Redox biology

Cremonini E,Daveri E,Mastaloudis A,Adamo AM,Mills D,Kalanetra K,Hester SN,Wood SM,Fraga CG,Oteiza PI

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Sun Sep 01 00:00:00 EDT 2019

Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis.

Redox biology

Cremonini E,Daveri E,Mastaloudis A,Adamo AM,Mills D,Kalanetra K,Hester SN,Wood SM,Fraga CG,Oteiza PI

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Sun Sep 01 00:00:00 EDT 2019

Protease-Activated Receptors 2-Antagonist Suppresses Asthma by Inhibiting Reactive Oxygen Species-Thymic Stromal Lymphopoietin Inflammation and Epithelial Tight Junction Degradation.

Allergy, asthma & immunology research

Kim HJ,Lee SH,Jeong S,Hong SJ

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Mon Jul 01 00:00:00 EDT 2019

Newly synthesized claudins but not occludin are added to the basal side of the tight junction.

Molecular biology of the cell

Van Itallie CM,Lidman KF,Tietgens AJ,Anderson JM

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Sat Jun 01 00:00:00 EDT 2019

Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs.

Tissue barriers

Chen H,Lu R,Zhang YG,Sun J

71-7800 was used in Western Blotting to study the role of the vitamin D receptor in lung barrier integrity.

Mon Apr 01 00:00:00 EDT 2019

Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity.

Cell reports

Lee S,Cieply B,Yang Y,Peart N,Glaser C,Chan P,Carstens RP

71-7800 was used in Immunocytochemistry-immunoflourescence to study the mechanisms by which Esrp ablation causes defects in epithelial barriers.

Tue Nov 27 00:00:00 EST 2018

HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model.

BioMed research international

Rodríguez-Uribe G,Serafín-Higuera N,Damian-Morales G,Cortés-Malagón EM,García-Hernández V,Verdejo-Torres O,Campos-Blázquez JP,Trejo-Muñoz CR,Contreras RG,Ocadiz-Delgado R,Palacios-Reyes C,Lambert PF,Griep AE,Mancilla-Percino T,Escobar-Herrera J,Álvarez-Ríos E,Ugarte-Briones C,Moreno J,Gariglio P,Bonilla-Delgado J

71-7800 was used in Immunohistochemistry on paraffin embedded tissues to determine if cataractous changes associated with Epithelium-Mesenchymal Transition occurring in the K14E6 mice lenses are associated with TGF-beta and Wnt/beta-catenin signalling activation.

Fri Oct 05 00:00:00 EDT 2018

Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum.

Scientific reports

Steenbergen R,Oti M,Ter Horst R,Tat W,Neufeldt C,Belovodskiy A,Chua TT,Cho WJ,Joyce M,Dutilh BE,Tyrrell DL

71-7800 was used in Immunocytochemistry-immunoflourescence to show that culturing human hepatoma cells in their native, adult serum (human serum, HS) results in the restoration of key morphological and metabolic features of normal liver cells.

Fri Aug 03 00:00:00 EDT 2018

Adherens junctions influence tight junction formation via changes in membrane lipid composition.

The Journal of cell biology

Shigetomi K,Ono Y,Inai T,Ikenouchi J

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunocytochemistry

Mon Jul 02 00:00:00 EDT 2018

Perineurial-like Cells and EMA Expression in the Suprachoroidal Region of the Human Eye.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Gilbert AR,Chévez-Barrios P,Cykowski MD

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry

Tue May 01 00:00:00 EDT 2018

VPS33B and VIPAR are essential for epidermal lamellar body biogenesis and function.

Biochimica et biophysica acta. Molecular basis of disease

Rogerson C,Gissen P

71-7800 was used in Immunohistochemistry-immunofluorescence to study the effects of mutations in VPS33B and VIPAS39 in ARC syndrome.

Tue May 01 00:00:00 EDT 2018

Analysis of the bystander effect in cone photoreceptors via a guided neural network platform.

Science advances

Ma Y,Han X,de Castro RB,Zhang P,Zhang K,Hu Z,Qin L

71-7800 was used in immunohistochemistry to develop a novel neural network chip (NN-Chip) platform suitable for studying signalling mechanisms in neurons, and through use of the NN-Chip, study the processes which lead to the bystander effect in cone photoreceptors.

Tue May 01 00:00:00 EDT 2018

(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance.

Redox biology

Cremonini E,Wang Z,Bettaieb A,Adamo AM,Daveri E,Mills DA,Kalanetra KM,Haj FG,Karakas S,Oteiza PI

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Sun Apr 01 00:00:00 EDT 2018

(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance.

Redox biology

Cremonini E,Wang Z,Bettaieb A,Adamo AM,Daveri E,Mills DA,Kalanetra KM,Haj FG,Karakas S,Oteiza PI

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Sun Apr 01 00:00:00 EDT 2018

Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation.

Scientific reports

Singh AP,Sharma S,Pagarware K,Siraji RA,Ansari I,Mandal A,Walling P,Aijaz S

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Tue Feb 27 00:00:00 EST 2018

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness.

The Journal of biological chemistry

Lee YK,Lim JJ,Jeoun UW,Min S,Lee EB,Kwon SM,Lee C,Yoon G

71-7800 was used in Western Blot to suggest that mitochondrial oxidative phosphorylation defects are initiated by lactate-mediated mitoribosomal deficiencies, promoting liver hepatocellular carcinoma development.

Fri Dec 08 00:00:00 EST 2017

Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer.

Oncology letters

Shimada H,Satohisa S,Kohno T,Konno T,Takano KI,Takahashi S,Hatakeyama T,Arimoto C,Saito T,Kojima T

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Fri Dec 01 00:00:00 EST 2017

Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer.

Oncology letters

Shimada H,Satohisa S,Kohno T,Konno T,Takano KI,Takahashi S,Hatakeyama T,Arimoto C,Saito T,Kojima T

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Fri Dec 01 00:00:00 EST 2017

Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer.

Oncology letters

Shimada H,Satohisa S,Kohno T,Konno T,Takano KI,Takahashi S,Hatakeyama T,Arimoto C,Saito T,Kojima T

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Fri Dec 01 00:00:00 EST 2017

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching.

Scientific reports

Ahmad R,Rah B,Bastola D,Dhawan P,Singh AB

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Tue Jul 11 00:00:00 EDT 2017

Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy.

PloS one

Fall B,Scott CR,Mauer M,Shankland S,Pippin J,Jefferson JA,Wallace E,Warnock D,Najafian B

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunocytochemistry

Wed Jul 05 00:00:00 EDT 2017

Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy.

PloS one

Fall B,Scott CR,Mauer M,Shankland S,Pippin J,Jefferson JA,Wallace E,Warnock D,Najafian B

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunocytochemistry

Wed Jul 05 00:00:00 EDT 2017

TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium.

Journal of cellular physiology

Martínez-Rendón J,Sánchez-Guzmán E,Rueda A,González J,Gulias-Cañizo R,Aquino-Jarquín G,Castro-Muñozledo F,García-Villegas R

71-7800 was used in immunocytochemistry and western blot to investigate the role of TRPV4 in a corneal epithelial cell model

Sat Jul 01 00:00:00 EDT 2017

Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.

The Journal of biological chemistry

Buzza MS,Johnson TA,Conway GD,Martin EW,Mukhopadhyay S,Shea-Donohue T,Antalis TM

71-7800 was used in Western Blotting to show that mRNA and protein expression of both matriptase and prostasin are rapidly down-regulated in the initiating inflammatory phases of dextran sulfate sodium (DSS)-induced experimental colitis in mice, and, significantly, the loss of these proteases precedes the appearance of clinical symptoms.

Fri Jun 30 00:00:00 EDT 2017

Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.

Oncogene

Guo JY,Hsu HS,Tyan SW,Li FY,Shew JY,Lee WH,Chen JY

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Thu Apr 27 00:00:00 EDT 2017

Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells.

The Journal of biological chemistry

Hichino A,Okamoto M,Taga S,Akizuki R,Endo S,Matsunaga T,Ikari A

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Feb 10 00:00:00 EST 2017

Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.

The Journal of clinical investigation

Wu CJ,Feng X,Lu M,Morimura S,Udey MC

71-7800 was used in western blot to test if HAI-2, matriptase, EpCAM, and claudin-7 are functionally linked in the intestine

Wed Feb 01 00:00:00 EST 2017

Epithelial response to a high-protein diet in rat colon.

BMC genomics

Beaumont M,Andriamihaja M,Armand L,Grauso M,Jaffrézic F,Laloë D,Moroldo M,Davila AM,Tomé D,Blachier F,Lan A

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Tue Jan 31 00:00:00 EST 2017

Salmonella enteritidis Effector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway.

The Journal of biological chemistry

Lin Z,Zhang YG,Xia Y,Xu X,Jiao X,Sun J

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Dec 23 00:00:00 EST 2016

Salmonella enteritidis Effector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway.

The Journal of biological chemistry

Lin Z,Zhang YG,Xia Y,Xu X,Jiao X,Sun J

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Dec 23 00:00:00 EST 2016

Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation.

Proceedings of the National Academy of Sciences of the United States of America

Yuan J,Cha J,Deng W,Bartos A,Sun X,Ho HH,Borg JP,Yamaguchi TP,Yang Y,Dey SK

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry (Paraffin)

Tue Dec 13 00:00:00 EST 2016

Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation.

Proceedings of the National Academy of Sciences of the United States of America

Yuan J,Cha J,Deng W,Bartos A,Sun X,Ho HH,Borg JP,Yamaguchi TP,Yang Y,Dey SK

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunohistochemistry (Paraffin)

Tue Dec 13 00:00:00 EST 2016

Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.

Inflammatory bowel diseases

Keppner A,Malsure S,Nobile A,Auberson M,Bonny O,Hummler E

717800 was used in western blot to assess the contribution of mutated prostasin in dextran sodium sulfate-induced colitis

Thu Dec 01 00:00:00 EST 2016

Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.

The Journal of biological chemistry

Fujii N,Matsuo Y,Matsunaga T,Endo S,Sakai H,Yamaguchi M,Yamazaki Y,Sugatani J,Ikari A

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Nov 18 00:00:00 EST 2016

Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.

The Journal of biological chemistry

Fujii N,Matsuo Y,Matsunaga T,Endo S,Sakai H,Yamaguchi M,Yamazaki Y,Sugatani J,Ikari A

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Nov 18 00:00:00 EST 2016

Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.

The Journal of biological chemistry

Fujii N,Matsuo Y,Matsunaga T,Endo S,Sakai H,Yamaguchi M,Yamazaki Y,Sugatani J,Ikari A

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Nov 18 00:00:00 EST 2016

Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.

The Journal of biological chemistry

Fujii N,Matsuo Y,Matsunaga T,Endo S,Sakai H,Yamaguchi M,Yamazaki Y,Sugatani J,Ikari A

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Nov 18 00:00:00 EST 2016

HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24.

Oncogene

Teo WW,Merino VF,Cho S,Korangath P,Liang X,Wu RC,Neumann NM,Ewald AJ,Sukumar S

71-7800 was used in western blot to elucidate regulation of E-cadherin and CD24 by determination of cell fate transition and impeding tumor initiation and progression in breast cancer via HOXA5

Thu Oct 20 00:00:00 EDT 2016

Dual effects of a high-protein diet on DSS-treated mice during colitis resolution phase.

American journal of physiology. Gastrointestinal and liver physiology

Lan A,Blais A,Coelho D,Capron J,Maarouf M,Benamouzig R,Lancha AH,Walker F,Tomé D,Blachier F

717800 was used in western blot to assess the effects of dietary protein using a model of colitis

Sat Oct 01 00:00:00 EDT 2016

Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo.

Hepatology (Baltimore, Md.)

Porat-Shliom N,Tietgens AJ,Van Itallie CM,Vitale-Cross L,Jarnik M,Harding OJ,Anderson JM,Gutkind JS,Weigert R,Arias IM

717800 was used in immunohistochemistry to use transgenic mice to clarify the role of LKB1 in the maintenance of functional tight junction

Sat Oct 01 00:00:00 EDT 2016

T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium.

PloS one

Strazielle N,Creidy R,Malcus C,Boucraut J,Ghersi-Egea JF

71-7800 was used in immunocytochemistry to study a reconstituted choroid plexus epithelium to show T-lymphocytes traffic into the brain across the blood-CSF barrier

Mon Jul 25 00:00:00 EDT 2016

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.

Nature communications

Banushi B,Forneris F,Straatman-Iwanowska A,Strange A,Lyne AM,Rogerson C,Burden JJ,Heywood WE,Hanley J,Doykov I,Straatman KR,Smith H,Bem D,Kriston-Vizi J,Ariceta G,Risteli M,Wang C,Ardill RE,Zaniew M,Latka-Grot J,Waddington SN,Howe SJ,Ferraro F,Gjinovci A,Lawrence S,Marsh M,Girolami M,Bozec L,Mills K,Gissen P

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Wed Jul 20 00:00:00 EDT 2016

Combined Treatment with Epigenetic, Differentiating, and Chemotherapeutic Agents Cooperatively Targets Tumor-Initiating Cells in Triple-Negative Breast Cancer.

Cancer research

Merino VF,Nguyen N,Jin K,Sadik H,Cho S,Korangath P,Han L,Foster YMN,Zhou XC,Zhang Z,Connolly RM,Stearns V,Ali SZ,Adams C,Chen Q,Pan D,Huso DL,Ordentlich P,Brodie A,Sukumar S

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Apr 01 00:00:00 EDT 2016

Defining a conformational consensus motif in cotransin-sensitive signal sequences: a proteomic and site-directed mutagenesis study.

PloS one

Klein W,Westendorf C,Schmidt A,Conill-Cortés M,Rutz C,Blohs M,Beyermann M,Protze J,Krause G,Krause E,Schülein R

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Mar 04 00:00:00 EST 2016

Proliferation of cultured mouse choroid plexus epithelial cells.

PloS one

Barkho BZ,Monuki ES

71-7800 was used in immunocytochemistry to show that choroid plexus epithelial cells expand in response to injury and growth factors

Fri Mar 04 00:00:00 EST 2016

Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice.

Scientific reports

Achamrah N,Nobis S,Breton J,Jésus P,Belmonte L,Maurer B,Legrand R,Bôle-Feysot C,do Rego JL,Goichon A,Rego JC,Déchelotte P,Fetissov SO,Claeyssens S,Coëffier M

71-7800 was used in western blot to study anorectic mice for improved body composition and intestinal hypermeability and behavior due to maintaining of physical activity during refeeding

Wed Feb 24 00:00:00 EST 2016

The impact of CLAUDIN-1 on follicular thyroid carcinoma aggressiveness.

Endocrine-related cancer

Zwanziger D,Badziong J,Ting S,Moeller LC,Schmid KW,Siebolts U,Wickenhauser C,Dralle H,Fuehrer D

71-7800 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to study follicular thyroid carcinoma aggressiveness caused by the impact of CLAUDIN-1

Thu Oct 01 00:00:00 EDT 2015

Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat Shock Factor 1 Activation, Leading to Hepatoma Cell Invasiveness.

The Journal of biological chemistry

Lee JH,Lee YK,Lim JJ,Byun HO,Park I,Kim GH,Xu WG,Wang HJ,Yoon G

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Aug 28 00:00:00 EDT 2015

Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat Shock Factor 1 Activation, Leading to Hepatoma Cell Invasiveness.

The Journal of biological chemistry

Lee JH,Lee YK,Lim JJ,Byun HO,Park I,Kim GH,Xu WG,Wang HJ,Yoon G

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Aug 28 00:00:00 EDT 2015

The characterization of the human nasal epithelial cell line RPMI 2650 under different culture conditions and their optimization for an appropriate in vitro nasal model.

Pharmaceutical research

Kreft ME,Jerman UD,Lasič E,Lanišnik Rižner T,Hevir-Kene N,Peternel L,Kristan K

71-7800 was used in immunocytochemistry to study using RPMI 2650 cells to create an in vitro model of the nasal mucosa.

Sun Feb 01 00:00:00 EST 2015

Alteration of intestinal barrier function during activity-based anorexia in mice.

Clinical nutrition (Edinburgh, Scotland)

Jésus P,Ouelaa W,François M,Riachy L,Guérin C,Aziz M,Do Rego JC,Déchelotte P,Fetissov SO,Coëffier M

71-7800 was used in immunocytochemistry to study the effect of activity-based anorexia on intestinal barrier function in mice

Mon Dec 01 00:00:00 EST 2014

Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel.

Toxicology and applied pharmacology

Wilmes A,Aschauer L,Limonciel A,Pfaller W,Jennings P

71-7800 was used in western blot to evaluate claudin 2 as a proximal tubular stress responsive paracellular water channel

Mon Sep 01 00:00:00 EDT 2014

Toll-like receptor 2 regulates the barrier function of human bronchial epithelial monolayers through atypical protein kinase C zeta, and an increase in expression of claudin-1.

Tissue barriers

Ragupathy S,Esmaeili F,Paschoud S,Sublet E,Citi S,Borchard G

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Thu Aug 07 00:00:00 EDT 2014

The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin.

PloS one

Shiobara T,Usui T,Han J,Isoda H,Nagumo Y

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Mon Jul 07 00:00:00 EDT 2014

The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin.

PloS one

Shiobara T,Usui T,Han J,Isoda H,Nagumo Y

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Mon Jul 07 00:00:00 EDT 2014

A bradykinin-potentiating peptide (BPP-10c) from Bothrops jararaca induces changes in seminiferous tubules.

The journal of venomous animals and toxins including tropical diseases

Gilio JM,Portaro FC,Borella MI,Lameu C,Camargo AC,Alberto-Silva C

71-7800 was used in immunohistochemistry to study the effects of the BPP-0c and captopril on the structure and function of the seminiferous epithelium.

Wed Nov 06 00:00:00 EST 2013

Papillomavirus E6 oncoprotein up-regulates occludin and ZO-2 expression in ovariectomized mice epidermis.

Experimental cell research

Hernández-Monge J,Garay E,Raya-Sandino A,Vargas-Sierra O,Díaz-Chávez J,Popoca-Cuaya M,Lambert PF,González-Mariscal L,Gariglio P

71-7800 was used in immunohistochemistry (frozen) to investigate the expression of the tight junction proteins occludin, claudin-1 and ZO-2 in the epidermis of female mice.

Tue Oct 15 00:00:00 EDT 2013

Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature.

Cell reports

Mayes DA,Rizvi TA,Titus-Mitchell H,Oberst R,Ciraolo GM,Vorhees CV,Robinson AP,Miller SD,Cancelas JA,Stemmer-Rachamimov AO,Ratner N

71-7800 was used in western blot to investigate the effects of antioxidants on Nf loss or HRas hyper activation in mouse oligodendrocytes.

Thu Sep 26 00:00:00 EDT 2013

Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes.

The Journal of investigative dermatology

Kirschner N,Rosenthal R,Furuse M,Moll I,Fromm M,Brandner JM

71-7800 was used in immunocytochemistry and western blot to examine the contribution of various tight junction proteins in keratinocytes.

Wed May 01 00:00:00 EDT 2013

Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier.

Biology open

Ortiz-Melo MT,Sánchez-Guzmán E,González-Robles A,Valdés J,Gómez-Flores E,Castro-Muñozledo F

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Fri Feb 15 00:00:00 EST 2013

Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier.

Biology open

Ortiz-Melo MT,Sánchez-Guzmán E,González-Robles A,Valdés J,Gómez-Flores E,Castro-Muñozledo F

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Fri Feb 15 00:00:00 EST 2013

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells.

Archives of toxicology

Limonciel A,Wilmes A,Aschauer L,Radford R,Bloch KM,McMorrow T,Pfaller W,van Delft JH,Slattery C,Ryan MP,Lock EA,Jennings P

71-7800 was used in immunocytochemistry and western blot to determine the effects of KBrO(3) using human and rat proximal tubular cell lines.

Thu Nov 01 00:00:00 EDT 2012

Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.

Journal of cell science

Guillemot L,Schneider Y,Brun P,Castagliuolo I,Pizzuti D,Martines D,Jond L,Bongiovanni M,Citi S

Thu Nov 01 00:00:00 EDT 2012

Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.

Journal of cell science

Guillemot L,Schneider Y,Brun P,Castagliuolo I,Pizzuti D,Martines D,Jond L,Bongiovanni M,Citi S

Thu Nov 01 00:00:00 EDT 2012

GLP-2 enhances barrier formation and attenuates TNFα-induced changes in a Caco-2 cell model of the intestinal barrier.

Regulatory peptides

Moran GW,O'Neill C,McLaughlin JT

71-7800 was used in western blot to test if GLP-2 regulates tight junctions.

Wed Oct 10 00:00:00 EDT 2012

Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells.

Journal of agricultural and food chemistry

Noda S,Tanabe S,Suzuki T

Wed May 09 00:00:00 EDT 2012

EGFR regulation of epidermal barrier function.

Physiological genomics

Tran QT,Kennedy LH,Leon Carrion S,Bodreddigari S,Goodwin SB,Sutter CH,Sutter TR

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Sun Apr 15 00:00:00 EDT 2012

EGFR regulation of epidermal barrier function.

Physiological genomics

Tran QT,Kennedy LH,Leon Carrion S,Bodreddigari S,Goodwin SB,Sutter CH,Sutter TR

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Sun Apr 15 00:00:00 EDT 2012

Tight junction proteins expression and modulation in immune cells and multiple sclerosis.

Journal of cellular and molecular medicine

Mandel I,Paperna T,Glass-Marmor L,Volkowich A,Badarny S,Schwartz I,Vardi P,Koren I,Miller A

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Sun Apr 01 00:00:00 EDT 2012

Functional characterization and localization of a gill-specific claudin isoform in Atlantic salmon.

American journal of physiology. Regulatory, integrative and comparative physiology

Engelund MB,Yu AS,Li J,Madsen SS,Færgeman NJ,Tipsmark CK

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Sun Jan 15 00:00:00 EST 2012

Functional characterization and localization of a gill-specific claudin isoform in Atlantic salmon.

American journal of physiology. Regulatory, integrative and comparative physiology

Engelund MB,Yu AS,Li J,Madsen SS,Færgeman NJ,Tipsmark CK

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Sun Jan 15 00:00:00 EST 2012

CD44 regulates tight-junction assembly and barrier function.

The Journal of investigative dermatology

Kirschner N,Haftek M,Niessen CM,Behne MJ,Furuse M,Moll I,Brandner JM

Fri Apr 01 00:00:00 EDT 2011

CD44 regulates tight-junction assembly and barrier function.

The Journal of investigative dermatology

Kirschner N,Haftek M,Niessen CM,Behne MJ,Furuse M,Moll I,Brandner JM

Fri Apr 01 00:00:00 EDT 2011

Expression of claudin-1 and -11 in immature and mature pheasant (Phasianus colchicus) testes.

Theriogenology

Park CJ,Lee JE,Oh YS,Shim S,Nah WH,Choi KJ,Gye MC

Tue Feb 01 00:00:00 EST 2011

Expression of claudin-1 and -11 in immature and mature pheasant (Phasianus colchicus) testes.

Theriogenology

Park CJ,Lee JE,Oh YS,Shim S,Nah WH,Choi KJ,Gye MC

Tue Feb 01 00:00:00 EST 2011

The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants.

The Biochemical journal

Churko JM,Langlois S,Pan X,Shao Q,Laird DW

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Sun Aug 01 00:00:00 EDT 2010

The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants.

The Biochemical journal

Churko JM,Langlois S,Pan X,Shao Q,Laird DW

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Sun Aug 01 00:00:00 EDT 2010

Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown.

The Journal of biological chemistry

Haurigot V,Villacampa P,Ribera A,Llombart C,Bosch A,Nacher V,Ramos D,Ayuso E,Segovia JC,Bueren JA,Ruberte J,Bosch F

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Aug 21 00:00:00 EDT 2009

Claudin expression modulations reflect an injury response in the murine epidermis.

The Journal of investigative dermatology

Arabzadeh A,Troy TC,Turksen K

71-7800 was used in immunohistochemistry to explore whether claudin expression modulations reflect an injury response in the murine epidermis

Tue Jan 01 00:00:00 EST 2008

Astrovirus increases epithelial barrier permeability independently of viral replication.

Journal of virology

Moser LA,Carter M,Schultz-Cherry S

71-7800 was used in immunocytochemistry to report that capsid contributes to astrovirus infection-induced diarrhea

Thu Nov 01 00:00:00 EDT 2007

Claudin immunolocalization in neonatal mouse epithelial tissues.

Cell and tissue research

Troy TC,Arabzadeh A,Yerlikaya S,Turksen K

71-7800 was used in immunohistochemistry - paraffin section to analyze the localizations of Cldn1, Cldn6, Cldn11, and Cldn18, and the presence of Cldn3 and Cldn5 in various neonatal mouse epithelia

Thu Nov 01 00:00:00 EDT 2007

Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis.

BMC cancer

Arabzadeh A,Troy TC,Turksen K

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Immunofluorescence

Thu Oct 18 00:00:00 EDT 2007

Dynamic changes in the cervical epithelial tight junction complex and differentiation occur during cervical ripening and parturition.

Endocrinology

Timmons BC,Mitchell SM,Gilpin C,Mahendroo MS

71-7800 was used in immunocytochemistry and western blot to study how the permeability barrier is regulated during pregnancy and parturition.

Thu Mar 01 00:00:00 EST 2007

Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules.

Biology direct

Tang VW

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Dec 08 00:00:00 EST 2006

Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.

Investigative ophthalmology & visual science

Xu H,Dawson R,Crane IJ,Liversidge J

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Jul 01 00:00:00 EDT 2005

Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.

Investigative ophthalmology & visual science

Xu H,Dawson R,Crane IJ,Liversidge J

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Jul 01 00:00:00 EDT 2005

Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.

Investigative ophthalmology & visual science

Xu H,Dawson R,Crane IJ,Liversidge J

Published figure using Claudin 1 polyclonal antibody (Product # 71-7800) in Western Blot

Fri Jul 01 00:00:00 EDT 2005

Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Go M,Kojima T,Takano K,Murata M,Ichimiya S,Tsubota H,Himi T,Sawada N

71-7800 was used in immunohistochemistry - frozen section to examine the expression and function of tight junctions in the epithelium of human palatine tonsils from patients with tonsillar hypertrophy or recurrent tonsillitis

Wed Dec 01 00:00:00 EST 2004

Simultaneous cell death and desquamation of the embryonic diffusion barrier during epidermal development.

Experimental cell research

Saathoff M,Blum B,Quast T,Kirfel G,Herzog V

71-7800 was used in immunohistochemistry - frozen section and western blot to identify tight junctions involved in the formation of the embryonic diffusion barrier

Fri Oct 01 00:00:00 EDT 2004

Connexin 26-mediated gap junctional intercellular communication suppresses paracellular permeability of human intestinal epithelial cell monolayers.

Experimental cell research

Morita H,Katsuno T,Hoshimoto A,Hirano N,Saito Y,Suzuki Y

71-7800 was used in western blot to examine the roles of gap junctional intercellular communication in the regulation of the barrier function of tight junctions

Sun Aug 01 00:00:00 EDT 2004

Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Bruewer M,Luegering A,Kucharzik T,Parkos CA,Madara JL,Hopkins AM,Nusrat A

Mon Dec 01 00:00:00 EST 2003

Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Bruewer M,Luegering A,Kucharzik T,Parkos CA,Madara JL,Hopkins AM,Nusrat A

Mon Dec 01 00:00:00 EST 2003

SRC-induced disintegration of adherens junctions of madin-darby canine kidney cells is dependent on endocytosis of cadherin and antagonized by Tiam-1.

Laboratory investigation; a journal of technical methods and pathology

Palovuori R,Sormunen R,Eskelinen S

71-7800 was used in immunoprecipitation to investigate the effects of Src tyrosine kinase activation in temperature sensitive-Src-transformed Madin-Darby canine kidney cells.

Mon Dec 01 00:00:00 EST 2003

Interferon-gamma down-regulates claudin-1 and impairs the epithelial barrier function in primary cultured human thyrocytes.

European journal of endocrinology

Tedelind S,Ericson LE,Karlsson JO,Nilsson M

71-7800 was used in immunohistochemistry and western blot to assess the effect of interferon-gamma on the barrier function of primary cultured human thyrocytes.

Mon Sep 01 00:00:00 EDT 2003

Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme.

Acta neuropathologica

Wolburg H,Wolburg-Buchholz K,Kraus J,Rascher-Eggstein G,Liebner S,Hamm S,Duffner F,Grote EH,Risau W,Engelhardt B

Sun Jun 01 00:00:00 EDT 2003

Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme.

Acta neuropathologica

Wolburg H,Wolburg-Buchholz K,Kraus J,Rascher-Eggstein G,Liebner S,Hamm S,Duffner F,Grote EH,Risau W,Engelhardt B

Sun Jun 01 00:00:00 EDT 2003

2,3-butanedione monoxime (BDM), a potent inhibitor of actin-myosin interaction, induces ion and fluid transport in MDCK monolayers.

Journal of muscle research and cell motility

Castillo AM,Reyes JL,Sánchez E,Mondragón R,Meza I

71-7800 was used in immunocytochemistry to investigate the role of myosin in vectorial transport

Fri May 30 00:00:00 EDT 2003

Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells.

Journal of virology

Nunbhakdi-Craig V,Craig L,Machleidt T,Sontag E

Sat Mar 01 00:00:00 EST 2003

Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells.

Journal of virology

Nunbhakdi-Craig V,Craig L,Machleidt T,Sontag E

Sat Mar 01 00:00:00 EST 2003

Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells.

Journal of virology

Nunbhakdi-Craig V,Craig L,Machleidt T,Sontag E

Sat Mar 01 00:00:00 EST 2003

Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells.

Journal of virology

Nunbhakdi-Craig V,Craig L,Machleidt T,Sontag E

Sat Mar 01 00:00:00 EST 2003

Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.

Journal of cell science

Brown RC,Mark KS,Egleton RD,Huber JD,Burroughs AR,Davis TP

Sat Feb 15 00:00:00 EST 2003

Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.

Journal of cell science

Brown RC,Mark KS,Egleton RD,Huber JD,Burroughs AR,Davis TP

Sat Feb 15 00:00:00 EST 2003

Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.

Journal of cell science

Brown RC,Mark KS,Egleton RD,Huber JD,Burroughs AR,Davis TP

Sat Feb 15 00:00:00 EST 2003

Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.

Journal of cell science

Brown RC,Mark KS,Egleton RD,Huber JD,Burroughs AR,Davis TP

Sat Feb 15 00:00:00 EST 2003

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

The Journal of cell biology

Nunbhakdi-Craig V,Machleidt T,Ogris E,Bellotto D,White CL,Sontag E

Mon Sep 02 00:00:00 EDT 2002

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

The Journal of cell biology

Nunbhakdi-Craig V,Machleidt T,Ogris E,Bellotto D,White CL,Sontag E

Mon Sep 02 00:00:00 EDT 2002

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

The Journal of cell biology

Nunbhakdi-Craig V,Machleidt T,Ogris E,Bellotto D,White CL,Sontag E

Mon Sep 02 00:00:00 EDT 2002

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

The Journal of cell biology

Nunbhakdi-Craig V,Machleidt T,Ogris E,Bellotto D,White CL,Sontag E

Mon Sep 02 00:00:00 EDT 2002

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

The Journal of cell biology

Nunbhakdi-Craig V,Machleidt T,Ogris E,Bellotto D,White CL,Sontag E

Mon Sep 02 00:00:00 EDT 2002

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

The Journal of cell biology

Nunbhakdi-Craig V,Machleidt T,Ogris E,Bellotto D,White CL,Sontag E

Mon Sep 02 00:00:00 EDT 2002

The renal segmental distribution of claudins changes with development.

Kidney international

Reyes JL,Lamas M,Martin D,del Carmen Namorado M,Islas S,Luna J,Tauc M,González-Mariscal L

71-7800 was used in immunohistochemistry (frozen) and western blot to examine the differential expression of occludin and several claudins in isolated renal tubules from newborn and adult rabbits.