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Proteintech
Claudin 3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
16456-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Claudin 3 Fusion Protein Ag9411 (1-220 aa encoded by BC016056)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSMGLEITG TALAVLGWLG TIVCCALPMW RVSAFIGSNI ITSQNIWEGL WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALIVVAILL AAFGLLVALV GAQCTNCVQD DTAKAKITIV AGVLFLLAAL LTLVPVSWSA NTIIRDFYNP VVPEAQKREM GAGLYVGWAA AALQLLGGAL LCCSCPPREK KYTATKVVYS APRSTGPGAS LGTGYDRKDY V (1-220 aa encoded by BC016056)
Target Information
Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CDS is longest ORF of a cDNA clone which hybridizes to a 1.2 kb transcript present at higher levels in the ventral prostate of 3-day castrate than in normal rats; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; RVP1; similar to rat ventral prostate 1 protein RVP1; unnamed protein product; ventral prostate.1 protein; ventral prostate.1 protein homolog; ventral prostate.1-like protein
Gene Aliases: C7orf1; CPE-R2; CPETR2; HRVP1; mRVP1; RVP1
UniProt ID: (Human) O15551, (Rat) Q63400, (Mouse) Q9Z0G9
Entrez Gene ID: (Human) 1365, (Rat) 65130, (Mouse) 12739
response to hypoxia
epithelial cell morphogenesis
retinal pigment epithelium development
cell adhesion
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
establishment of endothelial blood-brain barrier
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
regulation of cell morphogenesis
actin cytoskeleton organization
positive regulation of cell migration
negative regulation of cell migration
cell junction assembly
cell junction maintenance
maintenance of blood-brain barrier
cell-cell junction maintenance
response to ethanol
bicellular tight junction assembly
positive regulation of wound healing
regulation of membrane permeability
response to Gram-positive bacterium
regulation of transepithelial transport
negative regulation of phosphate transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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